Effects of TAK-676 on immune cell populations within the tumor-draining lymph nodes from mice bearing B16F10 tumors (left and middle) and CT26 tumors (right). All data shown are representative of at least three independent experiments. A, Frequency of total viable cells. B, Frequency of CD11⁺ MHCI⁺ cells. C, Frequency of CD8⁻ CD80⁺ DCs. D, Frequency of CD8⁻ CD86⁺ DCs. E, Frequency of IFNγ⁺ CD8⁺ T cells. F, Frequency of Ki67⁺ CD8⁺ T cells. G, Frequency of CD69⁺ CD8⁺ T cells. H, Frequency of CD11c⁺ MHCII⁺ cells. I, MFI of CD86 on DCs. J, MFI of CD80 on DCs. K, Frequency of CD69⁺ NK cells. **, P ≤ 0.01.