Stromal cell composition differences in RALP tissue samples with benign and MRI-annotated tissue areas. Marker-defined cell areas were normalized to the total stromal area. A, SMA-positive cell fraction. B, FAP-positive cell fraction. C, CD163-positive cell fraction. D, CD8-positive cell fraction. N(Be) = 309 patients, N(MRI-Neg) = 197 patients, N(MRI-Pos) = 302 patients. ***, P < 0.01. Boxplot boxes, interquartile range (IQR); error lines, data points within 1.5-fold IQR; circles, data points within 3-fold IQR; stars, extreme data points. Paired sample t test (normal distribution) or Mann–Whitney U test (nonnormal distribution) were used.