Chemokines, cytokines, and growth factors in patients showing stable disease. Note: Serum cytokine/chemokine/growth factor profiling. A, Superimposed scatter plot showing levels of cytokines, chemokines, and growth factors in patients JHU-008, JHU-011, and JHU-012 at week 4. Analytes showing greater changes (up or down) as compared with baseline are labeled in the plot and were selected for multi-timepoint analysis. B, Line graph showing levels (pg/mL) of CXCL10, CXCL9, and GCSF in serum samples of patients JHU-008 and JHU-012. C, Heatmap showing serum levels (pg/mL) of selected analytes from scatter plot for patient JHU-011. D, Superimposed scatter plot showing median levels of cytokines, chemokines, and growth factors in patients group showing either progressive or stable disease. Slope of the line indicate if a particular analyte was higher or lower in the stable disease group as compared with patients with progressive disease. Factors that show up or downregulation in the stable disease group are labeled in the plot. IL3 was removed from the temporal analysis because it was under the lower detection limit in all the subjects. IFNα2 was also removed from the investigation because it was either not detectable or unchanged compared with baseline levels.