American Association for Cancer Research

FIGURE 1

$p53 missense mutations are enriched in GBM and show a sex difference in incidence. A,TP53 mutation analysis from cBioPortal representing distribution of all truncating, missense, and in-frame TP53 mutations in glioblastoma, all CNS tumors, and pan-cancer analysis. B, The fraction of mutant TP53 tumors with missense mutations in the DBD (Missense – DBD) was compared with all other TP53 mutation types and TP53 domains (Other) in pan-cancer, GBM, CNS tumors, breast cancer, prostate cancer, lung cancer, skin cancer, and colorectal cancer. Significant enrichment or reduction compared with the pan cancer data set was determined by Fisher exact test. C, Analysis of the male to female ratio of TP53 missense mutations in GBM from TCGA, COSMIC, and IARC databases revealed six codons with a significant difference in the frequency of mutations in males and females. Bars are the ratio of male to female tumors with p53 mutated at each codon. The absolute mutation counts are labeled within each bar. Significance was determined by Fisher exact test. *, P < 0.05; **, P < 0.01; ***, P < 0.001; ****, P < 0.0001.$

p53 missense mutations are enriched in GBM and show a sex difference in incidence. A,TP53 mutation analysis from cBioPortal representing distribution of all truncating, missense, and in-frame TP53 mutations in glioblastoma, all CNS tumors, and pan-cancer analysis. B, The fraction of mutant TP53 tumors with missense mutations in the DBD (Missense – DBD) was compared with all other TP53 mutation types and TP53 domains (Other) in pan-cancer, GBM, CNS tumors, breast cancer, prostate cancer, lung cancer, skin cancer, and colorectal cancer. Significant enrichment or reduction compared with the pan cancer data set was determined by Fisher exact test. C, Analysis of the male to female ratio of TP53 missense mutations in GBM from TCGA, COSMIC, and IARC databases revealed six codons with a significant difference in the frequency of mutations in males and females. Bars are the ratio of male to female tumors with p53 mutated at each codon. The absolute mutation counts are labeled within each bar. Significance was determined by Fisher exact test. *, P < 0.05; **, P < 0.01; ***, P < 0.001; ****, P < 0.0001.

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