American Association for Cancer Research

Table 4

Multivariate survival analyses

Variables in model	No. of patients	No. of events	χ²	Δχ²	P
I. All patients
A. Base = LN⁺ + Size+ER+erbB-2	645	312	143.22
DFS
Base + Apoptosis^a	645	312	145.86	2.64	0.10
Base + Mitosis^b	645	312	143.48	0.26	0.62
Base + Mits⁻/10 HPFs	645	312	143.85	0.63	0.43
Base + MIB-1	645	312	146.22	3.53	0.06
B. Base = LN⁺ + Size+Grade+ER+erbB-2	618	235	134.54
DSS
Base + Apoptosis	618	235	135.21	0.07	0.41^c
Base + Mitosis	618	235	135.61	1.07	0.30
Base + Mits/10 HPFs	618	235	134.56	0.02	0.88^d
Base + MIB-1	618	235	137.17	2.63	0.10^d
II. LN− patients
A. Base = Size+Grade	307	101	19.92
DFS
Base + Apoptosis	307	101	21.37	1.45	0.23
Base + Mitosis	307	101	27.63	7.71	0.0055^c
Base + Mits/10 HPFs	307	101	21.46	1.54	0.21
Base + MIB-1	307	101	22.10	2.17	0.14^c
B. Base = Grade	308	72	8.57
DSS
Base + Apoptosis	308	72	8.67	0.10	0.76
Base + Mitosis	308	72	9.57	1.00	0.32^c
Base + Mits/10 HPFs	308	72	9.61	1.04	0.20^c
Base + MIB-1	308	72	10.21	1.64	0.020
III. LN+ patients
A. Base = LN⁺ + Size+ER+erbB-2	327	208	63.82
DFS
Base + Apoptosis	327	208	63.96	0.13	0.72
Base + Mitosis	327	208	67.94	4.11	0.043^e
Base + Mits/10 HPFs	327	208	65.72	1.90	0.17
Base + MIB-1	327	208	64.38	0.55	0.46
B. Base = LN⁺ + Age+ER+erbB-2	325	171	79.34
DSS
Base + Apoptosis	325	171	81.24	1.91	0.17
Base + Mitosis	325	171	81.05	1.72	0.19
Base + Mits/10 HPFs	325	171	79.44	0.10	0.75
Base + MIB-1	325	171	83.01	3.68	0.06

Variables in model	No. of patients	No. of events	χ²	Δχ²	P
I. All patients
A. Base = LN⁺ + Size+ER+erbB-2	645	312	143.22
DFS
Base + Apoptosis^a	645	312	145.86	2.64	0.10
Base + Mitosis^b	645	312	143.48	0.26	0.62
Base + Mits⁻/10 HPFs	645	312	143.85	0.63	0.43
Base + MIB-1	645	312	146.22	3.53	0.06
B. Base = LN⁺ + Size+Grade+ER+erbB-2	618	235	134.54
DSS
Base + Apoptosis	618	235	135.21	0.07	0.41^c
Base + Mitosis	618	235	135.61	1.07	0.30
Base + Mits/10 HPFs	618	235	134.56	0.02	0.88^d
Base + MIB-1	618	235	137.17	2.63	0.10^d
II. LN− patients
A. Base = Size+Grade	307	101	19.92
DFS
Base + Apoptosis	307	101	21.37	1.45	0.23
Base + Mitosis	307	101	27.63	7.71	0.0055^c
Base + Mits/10 HPFs	307	101	21.46	1.54	0.21
Base + MIB-1	307	101	22.10	2.17	0.14^c
B. Base = Grade	308	72	8.57
DSS
Base + Apoptosis	308	72	8.67	0.10	0.76
Base + Mitosis	308	72	9.57	1.00	0.32^c
Base + Mits/10 HPFs	308	72	9.61	1.04	0.20^c
Base + MIB-1	308	72	10.21	1.64	0.020
III. LN+ patients
A. Base = LN⁺ + Size+ER+erbB-2	327	208	63.82
DFS
Base + Apoptosis	327	208	63.96	0.13	0.72
Base + Mitosis	327	208	67.94	4.11	0.043^e
Base + Mits/10 HPFs	327	208	65.72	1.90	0.17
Base + MIB-1	327	208	64.38	0.55	0.46
B. Base = LN⁺ + Age+ER+erbB-2	325	171	79.34
DSS
Base + Apoptosis	325	171	81.24	1.91	0.17
Base + Mitosis	325	171	81.05	1.72	0.19
Base + Mits/10 HPFs	325	171	79.44	0.10	0.75
Base + MIB-1	325	171	83.01	3.68	0.06

Apoptotic count per 1000.

Mitotic count per 1000.

Grade was not significant.

Grade and ER were not significant.

Size was no longer significant.