Correlation between apoptotic counts per 1000 and other markers
Markers . | All patients . | . | . | . | LN− . | . | . | . | LN+ . | . | . | . | |||||||||
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
. | n . | r . | 95% CIa . | P . | n . | r . | 95% CI . | P . | n . | r . | 95% CI . | P . | |||||||||
Age | 791 | −0.16 | (−0.23–−0.10) | <0.0001 | 331 | −0.15 | (−0.26–−0.04) | 0.0057 | 335 | −0.11 | (−0.21–−0.00) | 0.0472 | |||||||||
Elston grade | 755 | 0.40 | (0.33–0.45) | <0.0001 | 314 | 0.45 | (−0.35–0.53) | <0.0001 | 320 | 0.37 | (0.27 –0.46) | <0.0001 | |||||||||
Tumor size | 790 | 0.08 | (0.01–0.15) | 0.0304 | 331 | 0.06 | (−0.04–0.17) | NS | 334 | 0.09 | (−0.01–0.20) | NS | |||||||||
LN mets | 666 | −0.001 | (−0.08–0.08) | NS− | 335 | −0.026 | (−0.13–0.08) | NS | |||||||||||||
ER | 781 | −0.29 | (−0.35–−0.22) | <0.0001 | 328 | −0.34 | (−0.43–−0.24) | <0.0001 | 333 | −0.25 | (−0.35 –−0.15) | <0.0001 | |||||||||
MIB-1 | 791 | 0.36 | (0.30–0.42) | <0.0001 | 331 | 0.36 | (0.26–0.45) | <0.0001 | 335 | 0.32 | (0.22 –0.42) | <0.0001 | |||||||||
Mits/1000 | 791 | 0.46 | (0.41–0.52) | <0.0001 | 331 | 0.54 | (0.46–0.61) | <0.0001 | 335 | 0.39 | (0.30 –0.48) | <0.0001 | |||||||||
Mits/10 HPFs | 791 | 0.32 | (0.25–0.38) | <0.0001 | 331 | 0.33 | (0.23–0.42) | <0.0001 | 335 | 0.28 | (0.18 –0.38) | <0.0001 | |||||||||
p53 | 788 | 0.22 | (0.15–0.29) | <0.0001 | 330 | 0.30 | (0.20–0.39) | <0.0001 | 334 | 0.14 | (0.04 –0.25) | 0.0095 | |||||||||
erbB-2 | 787 | 0.20 | (0.13–0.26) | <0.0001 | 330 | 0.15 | (0.04–0.25) | 0.0071 | 335 | 0.25 | (0.15 –0.35) | <0.0001 | |||||||||
Apoptosis by TUNEL | 232 | 1.15 | (0.02–0.27) | 0.0238 | 104 | 0.08 | (−0.11–0.27) | NS | 91 | 0.23 | (0.03–0.42) | 0.0260 |
Markers . | All patients . | . | . | . | LN− . | . | . | . | LN+ . | . | . | . | |||||||||
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
. | n . | r . | 95% CIa . | P . | n . | r . | 95% CI . | P . | n . | r . | 95% CI . | P . | |||||||||
Age | 791 | −0.16 | (−0.23–−0.10) | <0.0001 | 331 | −0.15 | (−0.26–−0.04) | 0.0057 | 335 | −0.11 | (−0.21–−0.00) | 0.0472 | |||||||||
Elston grade | 755 | 0.40 | (0.33–0.45) | <0.0001 | 314 | 0.45 | (−0.35–0.53) | <0.0001 | 320 | 0.37 | (0.27 –0.46) | <0.0001 | |||||||||
Tumor size | 790 | 0.08 | (0.01–0.15) | 0.0304 | 331 | 0.06 | (−0.04–0.17) | NS | 334 | 0.09 | (−0.01–0.20) | NS | |||||||||
LN mets | 666 | −0.001 | (−0.08–0.08) | NS− | 335 | −0.026 | (−0.13–0.08) | NS | |||||||||||||
ER | 781 | −0.29 | (−0.35–−0.22) | <0.0001 | 328 | −0.34 | (−0.43–−0.24) | <0.0001 | 333 | −0.25 | (−0.35 –−0.15) | <0.0001 | |||||||||
MIB-1 | 791 | 0.36 | (0.30–0.42) | <0.0001 | 331 | 0.36 | (0.26–0.45) | <0.0001 | 335 | 0.32 | (0.22 –0.42) | <0.0001 | |||||||||
Mits/1000 | 791 | 0.46 | (0.41–0.52) | <0.0001 | 331 | 0.54 | (0.46–0.61) | <0.0001 | 335 | 0.39 | (0.30 –0.48) | <0.0001 | |||||||||
Mits/10 HPFs | 791 | 0.32 | (0.25–0.38) | <0.0001 | 331 | 0.33 | (0.23–0.42) | <0.0001 | 335 | 0.28 | (0.18 –0.38) | <0.0001 | |||||||||
p53 | 788 | 0.22 | (0.15–0.29) | <0.0001 | 330 | 0.30 | (0.20–0.39) | <0.0001 | 334 | 0.14 | (0.04 –0.25) | 0.0095 | |||||||||
erbB-2 | 787 | 0.20 | (0.13–0.26) | <0.0001 | 330 | 0.15 | (0.04–0.25) | 0.0071 | 335 | 0.25 | (0.15 –0.35) | <0.0001 | |||||||||
Apoptosis by TUNEL | 232 | 1.15 | (0.02–0.27) | 0.0238 | 104 | 0.08 | (−0.11–0.27) | NS | 91 | 0.23 | (0.03–0.42) | 0.0260 |
CI, confidence interval; NS, not significant; mets, metastases; Mits, mitoses.