American Association for Cancer Research

Table 1

Apoptosis and proliferation data (medians) for breast cancer patients

Markers	All patients (n = 791)	LN− (n = 331)	LN+ (n = 331)	P ^a
Apoptosis^b	3.7	3.4	4.1	NS^c
Mitosis^d	2.3	1.7	3.1	0.0051
A:M ratio	1.50	1.56	1.60	NS
Mitoses/10 HPFs	6	5	8	NS
MIB-1 (%)^e	17.8	16.7	19.5	0.0066

Markers	All patients (n = 791)	LN− (n = 331)	LN+ (n = 331)	P ^a
Apoptosis^b	3.7	3.4	4.1	NS^c
Mitosis^d	2.3	1.7	3.1	0.0051
A:M ratio	1.50	1.56	1.60	NS
Mitoses/10 HPFs	6	5	8	NS
MIB-1 (%)^e	17.8	16.7	19.5	0.0066

Represents value of statistical difference between node-negative and node-positive subsets for each variable.

Apoptotic count per 1000.

NS, not significant.

Mitotic count per 1000.

Percentage of cells that are MIB-1-positive.