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Table 1

BM findings according to the age, disease stage, and cytogenetic aberrations of the primary tumor of 41 NB patients identified by the automatic microscopic procedure

Tumor cell positivity was stated when the tumor typical cytogenetic aberrations were found in at least two GD2 immunolabeled cells by a targeted sequential FISH analysis after automatic repositioning (GD2+/FISH+).
PatientAgeaDisease stageGenetic aberration in the primary tumorNo. of punctionGD2+ samplesGD2+/FISH+ samples
9 m del1p 
4 y Trisomy 1 and 2 
13 m Pentasomy 1 
3 m 2B Trisomy 1 and 2 
11 m 2B del1p 
11 m 2B imb1p, 17q gain 
4 y 17q gain 
10 m Trisomy 1 and 2 
4 y n.t.b 
10 11 m Tri- and hexasomy 1 and 2 
11 3 y MYCN ampl 
12 12 m 17q gain 
13 3 y del1p, MYCN ampl 
14 2 y Tri- and tetrasomy 1 and 2 
15 3 y 17q gain 
16 12 y 17q gain 
17 2 y 17q gain 
18 2 y imb1p 
19 6 y del1p 
20 12 y del1p 
21 8 m del1p 
22 4 y imb1p 
23 15 m del1p, MYCN ampl 
24 14 m del1p, MYCN ampl 
25 3 y del1p, gain MYCN 
26 2 y del1p, MYCN ampl 
27 3 y del1p, gain MYCN 
28 4 y del1p, MYCN ampl, 17q gain 
29 2 y del1p, MYCN ampl, 17q gain 
30 4 y imb1p, MYCN ampl, 17q gain 
31 5 y del1p, MYCN ampl, 17q gain 
32 18 m imb1p, MYCN ampl, 17q gain 
33 5 y del1p, MYCN ampl, 17q gain 
34 2 y del1p, MYCN ampl, 17q gain 
35 2 m 4s Trisomy 1 
36 1 m 4s Trisomy 1 
37 10 m 4s Trisomy 1 and 2 
38 4 m 4s Trisomy 1 and 2 
39 5 m 4s Tetrasomy 1 
40 13 m 4s Tri- and tetrasomy 17 
Tumor cell positivity was stated when the tumor typical cytogenetic aberrations were found in at least two GD2 immunolabeled cells by a targeted sequential FISH analysis after automatic repositioning (GD2+/FISH+).
PatientAgeaDisease stageGenetic aberration in the primary tumorNo. of punctionGD2+ samplesGD2+/FISH+ samples
9 m del1p 
4 y Trisomy 1 and 2 
13 m Pentasomy 1 
3 m 2B Trisomy 1 and 2 
11 m 2B del1p 
11 m 2B imb1p, 17q gain 
4 y 17q gain 
10 m Trisomy 1 and 2 
4 y n.t.b 
10 11 m Tri- and hexasomy 1 and 2 
11 3 y MYCN ampl 
12 12 m 17q gain 
13 3 y del1p, MYCN ampl 
14 2 y Tri- and tetrasomy 1 and 2 
15 3 y 17q gain 
16 12 y 17q gain 
17 2 y 17q gain 
18 2 y imb1p 
19 6 y del1p 
20 12 y del1p 
21 8 m del1p 
22 4 y imb1p 
23 15 m del1p, MYCN ampl 
24 14 m del1p, MYCN ampl 
25 3 y del1p, gain MYCN 
26 2 y del1p, MYCN ampl 
27 3 y del1p, gain MYCN 
28 4 y del1p, MYCN ampl, 17q gain 
29 2 y del1p, MYCN ampl, 17q gain 
30 4 y imb1p, MYCN ampl, 17q gain 
31 5 y del1p, MYCN ampl, 17q gain 
32 18 m imb1p, MYCN ampl, 17q gain 
33 5 y del1p, MYCN ampl, 17q gain 
34 2 y del1p, MYCN ampl, 17q gain 
35 2 m 4s Trisomy 1 
36 1 m 4s Trisomy 1 
37 10 m 4s Trisomy 1 and 2 
38 4 m 4s Trisomy 1 and 2 
39 5 m 4s Tetrasomy 1 
40 13 m 4s Tri- and tetrasomy 17 
a

m, month; y, year.

b

n.t., not tested.

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