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Table 1

Clinical trials using glutamine to prevent toxicity from chemotherapy

Author (Ref.)n                  aChemotherapyGlutamine dose (po)Results
Rubio (10) 9 MTXb 0.5 g/kg/day No mucositis seen 
Skubitz (19) 14 varied 4 g BID × 28 days Decreased stomatitis 
Savarese (7) 5 paclitaxelc 10 g TID × 4 days Prevention of myalgias/arthralgias 
Ohkuno (16) 66 5FU 4 g BID × 14 days No difference in mucositis from controls 
Author (Ref.)n                  aChemotherapyGlutamine dose (po)Results
Rubio (10) 9 MTXb 0.5 g/kg/day No mucositis seen 
Skubitz (19) 14 varied 4 g BID × 28 days Decreased stomatitis 
Savarese (7) 5 paclitaxelc 10 g TID × 4 days Prevention of myalgias/arthralgias 
Ohkuno (16) 66 5FU 4 g BID × 14 days No difference in mucositis from controls 
a

n, number of patients; MTX, methotrexate; BID, twice a day; 5 FU, 5-fluorouracil.

b

Escalating dose methotrexate from 40 to 100 mg/m2.

c

Paclitaxel-containing regimen.

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