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Table 1

The clinical characteristics, family histories, and mutational analysis of the BRCA1 gene in 76 patients with breast cancer diagnosis before age 45 years

Patient	Age (yrs)	ER status	TD status	Exon/codon	Nucleotide change	Family history of
Patient	Age (yrs)	ER status	TD status	Exon/codon	Nucleotide change							Breast (yr)	Ovarian
1	35	ER−	TD2	11A/464	1510del C, ter 474	None	None
2	37	ER−	TD3	11A /468	1523delG, ter 475	None	None
3	34	ER+	TD1	11B /770	2430insC, ter 776	None	None
4	39	ER−	TD3	11C/1088	3378/81delG, ter 1108	None	None
5	39	ER−	TD3	11B/871	2732insT, ter 902	MA (39)^a	None
6	33	ER−	TD3	13/1443	4446C →T, ter 1443	M (60)	None
						MGM (50)
						MA (46)
7	39	ER−	TD3	11C/1183	3667A →G,LK1183AR	None	None
					3240T →A,SS1040T
8	38	ER−	TD3	9/119	690G →A, Va191I	None	None

Patient	Age (yrs)	ER status	TD status	Exon/codon	Nucleotide change	Family history of
Patient	Age (yrs)	ER status	TD status	Exon/codon	Nucleotide change							Breast (yr)	Ovarian
1	35	ER−	TD2	11A/464	1510del C, ter 474	None	None
2	37	ER−	TD3	11A /468	1523delG, ter 475	None	None
3	34	ER+	TD1	11B /770	2430insC, ter 776	None	None
4	39	ER−	TD3	11C/1088	3378/81delG, ter 1108	None	None
5	39	ER−	TD3	11B/871	2732insT, ter 902	MA (39)^a	None
6	33	ER−	TD3	13/1443	4446C →T, ter 1443	M (60)	None
						MGM (50)
						MA (46)
7	39	ER−	TD3	11C/1183	3667A →G,LK1183AR	None	None
					3240T →A,SS1040T
8	38	ER−	TD3	9/119	690G →A, Va191I	None	None

^a

MA, maternal aunt; M, mother; MGM, maternal grandmother.