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Table 2

Kinetic parameters for BG inhibition of phenacetin O-deethylation and DTIC N-demethylation

SubstratesEnzymeIC50 (μm)Apparent Ki (μm)Type of inhibition
Phenacetin CYP1A2 5.0 ± 1.7 1.1 ± 0.1 Mixed 
DTIC (1 mm) Microsomes 2.8 ± 0.7   
DTIC (150 μm) Microsomes 1.5 ± 0.16   
DTIC CYP1A1 0.13 ± 0.02 0.19 ± 0.08 Mixed 
DTIC CYP1A2 3.8 ± 1.1 1.3 ± 0.2 Mixed 
SubstratesEnzymeIC50 (μm)Apparent Ki (μm)Type of inhibition
Phenacetin CYP1A2 5.0 ± 1.7 1.1 ± 0.1 Mixed 
DTIC (1 mm) Microsomes 2.8 ± 0.7   
DTIC (150 μm) Microsomes 1.5 ± 0.16   
DTIC CYP1A1 0.13 ± 0.02 0.19 ± 0.08 Mixed 
DTIC CYP1A2 3.8 ± 1.1 1.3 ± 0.2 Mixed 
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