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Table 1

Kinetic parameters for metabolism of BG, 8-oxoBG and DTIC

Substrates	Enzyme	K_M (μm)	V_max (pmol/min/pmol)	V_max/K_M
BG	CYP1A1	6.4 ± 0.4	0.5 ± 0.09	0.08
BG^a	CYP1A2	1.3 ± 0.08	1.7 ± 0.04	1.31
BG^a	CYP3A4	52.2 ± 7.14	0.3 ± 0.01	0.0057
8-oxoBG	CYP1A1	18.3 ± 1.3	3.1 ± 0.07	0.17
8-oxoBG^b	CYP1A2	35.9 ± 12.8	0.6 ± 0.2	0.016
DTIC	CYP1A1	306 ± 24	477 ± 145	1.56
DTIC	CYP1A2	327 ± 16	165 ± 7	0.51

Substrates	Enzyme	K_M (μm)	V_max (pmol/min/pmol)	V_max/K_M
BG	CYP1A1	6.4 ± 0.4	0.5 ± 0.09	0.08
BG^a	CYP1A2	1.3 ± 0.08	1.7 ± 0.04	1.31
BG^a	CYP3A4	52.2 ± 7.14	0.3 ± 0.01	0.0057
8-oxoBG	CYP1A1	18.3 ± 1.3	3.1 ± 0.07	0.17
8-oxoBG^b	CYP1A2	35.9 ± 12.8	0.6 ± 0.2	0.016
DTIC	CYP1A1	306 ± 24	477 ± 145	1.56
DTIC	CYP1A2	327 ± 16	165 ± 7	0.51

^a

Data cited from Roy et al. (13).

^b

Data cited from Long et al. (14).