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Table 1

Kinetic parameters for metabolism of BG, 8-oxoBG and DTIC

SubstratesEnzymeKMm)Vmax (pmol/min/pmol)Vmax/KM
BG CYP1A1 6.4 ± 0.4 0.5 ± 0.09 0.08 
BGa CYP1A2 1.3 ± 0.08 1.7 ± 0.04 1.31 
BGa CYP3A4 52.2 ± 7.14 0.3 ± 0.01 0.0057 
8-oxoBG CYP1A1 18.3 ± 1.3 3.1 ± 0.07 0.17 
8-oxoBGb CYP1A2 35.9 ± 12.8 0.6 ± 0.2 0.016 
DTIC CYP1A1 306 ± 24 477 ± 145 1.56 
DTIC CYP1A2 327 ± 16 165 ± 7 0.51 
SubstratesEnzymeKMm)Vmax (pmol/min/pmol)Vmax/KM
BG CYP1A1 6.4 ± 0.4 0.5 ± 0.09 0.08 
BGa CYP1A2 1.3 ± 0.08 1.7 ± 0.04 1.31 
BGa CYP3A4 52.2 ± 7.14 0.3 ± 0.01 0.0057 
8-oxoBG CYP1A1 18.3 ± 1.3 3.1 ± 0.07 0.17 
8-oxoBGb CYP1A2 35.9 ± 12.8 0.6 ± 0.2 0.016 
DTIC CYP1A1 306 ± 24 477 ± 145 1.56 
DTIC CYP1A2 327 ± 16 165 ± 7 0.51 
a

Data cited from Roy et al. (13).

b

Data cited from Long et al. (14).

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