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Table 4

In vivo apoptosis of endothelial cells in athymic nude mice treated with paclitaxel alone, Mab DC101 alone, or both after orthotopic implantation of human TCC of the bladder

Treatment groupApoptosis index for endothelial cellsa
Control (PBS) 0.9 ± 0.8 (0.0–1.6) 
Paclitaxel only 9.9 ± 4.9 (2.6–14.5)b 
DC101 only 19.9 ± 10.3 (9.1–36.8)b 
Paclitaxel plus DC101 30.9 ± 11.8 (17.6–50.0)c 
Treatment groupApoptosis index for endothelial cellsa
Control (PBS) 0.9 ± 0.8 (0.0–1.6) 
Paclitaxel only 9.9 ± 4.9 (2.6–14.5)b 
DC101 only 19.9 ± 10.3 (9.1–36.8)b 
Paclitaxel plus DC101 30.9 ± 11.8 (17.6–50.0)c 
a

The density of apoptosis for endothelial cells of microvessels (as measured by double staining). Immunofluorescence was expressed as the average for apoptosis in all endothelial cells for the five areas of highest microvessel density identified within a single ×200 field.

b

P < 0.005 against CTRL.

c

P < 0.005 against control and paclitaxel (Mann-Whitney statistical comparison).

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