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Table 1

Range of concentrations of the drugs combined with phenylacetate and phenylbutyrate in these experiments with the 8226 and MY5 human myeloma cell linesa

Drug8226 (μm)MY5 (μm)Concentrations in μm achievable in humans (reference)
Doxorubicin 0.01–0.12 0.01–0.16 0.01–7 (596061) 
Etoposide 0.05–1.8 0.05–0.35 10–92 (62) 
Topotecan 0.05–0.5 0.1–2 0.01–0.1 (63, 64) 
Cytarabine 0.2–4 0.05–1 10–150 (65) 
Chlorambucil 5–120 10–125 2–6.3 (66, 67) 
Melphalan 1–80 2–30 1–13 (68, 69) 
Fludarabine 5–180 3–40 0.63–0.76 (70) 
Cisplatin 0.5–12 1–20 8–30 (717273) 
Carboplatin 8–130 10–160 1.4–13.5 (74) 
Phenylacetate 2000–20,000 2000–20,000 1360–4600 (28, 42, 43) 
Phenylbutyrate 250–3000 250–3000 1120–2020 (23, 29, 75) 
Drug8226 (μm)MY5 (μm)Concentrations in μm achievable in humans (reference)
Doxorubicin 0.01–0.12 0.01–0.16 0.01–7 (596061) 
Etoposide 0.05–1.8 0.05–0.35 10–92 (62) 
Topotecan 0.05–0.5 0.1–2 0.01–0.1 (63, 64) 
Cytarabine 0.2–4 0.05–1 10–150 (65) 
Chlorambucil 5–120 10–125 2–6.3 (66, 67) 
Melphalan 1–80 2–30 1–13 (68, 69) 
Fludarabine 5–180 3–40 0.63–0.76 (70) 
Cisplatin 0.5–12 1–20 8–30 (717273) 
Carboplatin 8–130 10–160 1.4–13.5 (74) 
Phenylacetate 2000–20,000 2000–20,000 1360–4600 (28, 42, 43) 
Phenylbutyrate 250–3000 250–3000 1120–2020 (23, 29, 75) 
a

Also included are concentrations of these drugs achievable in humans.

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