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Table 3

Alteration of degree of methylation and MDR1 gene expression during the clinical course

ConditionDegree of methylation (MM2 % + MM4 %)aMDR1 gene expressionbTreatments
Case 1    
Primary tumor 54 0.5 None 
Recurrent tumor 16 4.2 Epirubicin 
Case 2    
Primary tumor 54 0.8 None 
Recurrent tumor 25 4.7 THP-ADMc 
Case 3    
Primary tumor 11 1.6 None 
Residual tumor 10.9 Systemic 
Case 4    
Recurrent tumor (Patient 3-1) 21 8.3 Epirubicin 
Residual tumor (Patient 3-2) 19.9 Systemic 
ConditionDegree of methylation (MM2 % + MM4 %)aMDR1 gene expressionbTreatments
Case 1    
Primary tumor 54 0.5 None 
Recurrent tumor 16 4.2 Epirubicin 
Case 2    
Primary tumor 54 0.8 None 
Recurrent tumor 25 4.7 THP-ADMc 
Case 3    
Primary tumor 11 1.6 None 
Residual tumor 10.9 Systemic 
Case 4    
Recurrent tumor (Patient 3-1) 21 8.3 Epirubicin 
Residual tumor (Patient 3-2) 19.9 Systemic 
a

Degree of methylation was analyzed using PCR (Fig. 5) and is represented as a percentage.

b

MDR1 expression was determined as described in legend to Fig. 4.

c

THP-ADM, pirarubisin.

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