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Table 3

T-cell responses in vitro correlate with peptide-specific DTH responses in vivo

Two patients completed all of the six immunizations and were skin-tested to the peptide components of their vaccine and GM-CSF individually. A, patient CZ8474. Skin test was performed 1 month after the sixth and final ECD vaccination. One-hundred μg of each HER-2/neu peptide was placed separately from 100 μg of GM-CSF i.d., and induration was measured at 48 h. B, patient CC7062. Skin test was performed 1 month after the sixth and final ICD vaccination. One-hundred μg of HER-2/neu peptides were placed separately from 100 μg of GM-CSF i.d., and induration was measured at 48 h.
Antigen testedInduration (mm) 48 h
A. CZ8474
p42 15 × 12 
p98 12 × 12 
p328 8 × 10 
p971 
Sterile water 
GM-CSF 
Two patients completed all of the six immunizations and were skin-tested to the peptide components of their vaccine and GM-CSF individually. A, patient CZ8474. Skin test was performed 1 month after the sixth and final ECD vaccination. One-hundred μg of each HER-2/neu peptide was placed separately from 100 μg of GM-CSF i.d., and induration was measured at 48 h. B, patient CC7062. Skin test was performed 1 month after the sixth and final ICD vaccination. One-hundred μg of HER-2/neu peptides were placed separately from 100 μg of GM-CSF i.d., and induration was measured at 48 h.
Antigen testedInduration (mm) 48 h
A. CZ8474
p42 15 × 12 
p98 12 × 12 
p328 8 × 10 
p971 
Sterile water 
GM-CSF 
B. CC7062
p776 11 × 11 
p927 10 × 10 
p1166 4 × 3 
p98 6 × 6 
Sterile water 
GM-CSF 
B. CC7062
p776 11 × 11 
p927 10 × 10 
p1166 4 × 3 
p98 6 × 6 
Sterile water 
GM-CSF 
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