American Association for Cancer Research

Table 3

T-cell responses in vitro correlate with peptide-specific DTH responses in vivo

Two patients completed all of the six immunizations and were skin-tested to the peptide components of their vaccine and GM-CSF individually. A, patient CZ8474. Skin test was performed 1 month after the sixth and final ECD vaccination. One-hundred μg of each HER-2/neu peptide was placed separately from 100 μg of GM-CSF i.d., and induration was measured at 48 h. B, patient CC7062. Skin test was performed 1 month after the sixth and final ICD vaccination. One-hundred μg of HER-2/neu peptides were placed separately from 100 μg of GM-CSF i.d., and induration was measured at 48 h.
Antigen tested	Induration (mm) 48 h
A. CZ8474
p42	15 × 12
p98	12 × 12
p328	8 × 10
p971	0
Sterile water	0
GM-CSF	0

Two patients completed all of the six immunizations and were skin-tested to the peptide components of their vaccine and GM-CSF individually. A, patient CZ8474. Skin test was performed 1 month after the sixth and final ECD vaccination. One-hundred μg of each HER-2/neu peptide was placed separately from 100 μg of GM-CSF i.d., and induration was measured at 48 h. B, patient CC7062. Skin test was performed 1 month after the sixth and final ICD vaccination. One-hundred μg of HER-2/neu peptides were placed separately from 100 μg of GM-CSF i.d., and induration was measured at 48 h.
Antigen tested	Induration (mm) 48 h
A. CZ8474
p42	15 × 12
p98	12 × 12
p328	8 × 10
p971	0
Sterile water	0
GM-CSF	0