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Table 3

Characteristics of the tumors according to high (groups B and D) or low (groups A and C) vessel density

Groups B and DGroups A and CP
Vessel density 17.1 ± 11.0 3.1 ± 1.7 <0.0001 
PCNA index (%) 28.1 ± 18.5 21.9 ± 16.0 0.07 
Apoptosis 0.44 ± 0.34 0.29 ± 0.24 0.01 
VEGF    
 Positive 27 (67%) 24 (51%) 0.12 
 Negative 13 23  
bFGF    
 Positive 27 (73%) 27 (63%) 0.33 
 Negative 10 16  
PDGF    
 Positive 18 (51%) 24 (57%) 0.61 
 Negative 17 18  
Growth in mice    
 Yes f7 (27%) 20 (57%) 0.01 
 No 19 15  
Metastasisa    
 Positive 27 (67%) 28 (61%) 0.52 
 Negative 13 18  
Survival (weeks) 111 64 0.20 
Groups B and DGroups A and CP
Vessel density 17.1 ± 11.0 3.1 ± 1.7 <0.0001 
PCNA index (%) 28.1 ± 18.5 21.9 ± 16.0 0.07 
Apoptosis 0.44 ± 0.34 0.29 ± 0.24 0.01 
VEGF    
 Positive 27 (67%) 24 (51%) 0.12 
 Negative 13 23  
bFGF    
 Positive 27 (73%) 27 (63%) 0.33 
 Negative 10 16  
PDGF    
 Positive 18 (51%) 24 (57%) 0.61 
 Negative 17 18  
Growth in mice    
 Yes f7 (27%) 20 (57%) 0.01 
 No 19 15  
Metastasisa    
 Positive 27 (67%) 28 (61%) 0.52 
 Negative 13 18  
Survival (weeks) 111 64 0.20 
a

One case could not be defined.

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