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Table 2

Characteristics of squamous cell lung carcinomas subdivided according to PCNA index and vessel density

Group AGroup BGroup CGroup D
PCNA index (%) 37.7 ± 10.4 42.1 ± 12.6 10.3 ± 6.4 11.0 ± 5.6 
Vessel density 2.7 ± 1.5 18.3 ± 12.7 3.4 ± 1.9 15.6 ± 8.5 
Apoptosis 0.31 ± 0.21 0.47 ± 0.35 0.28 ± 0.26 0.40 ± 0.34 
Pa  0.07 0.14 0.27 
VEGF     
 Positive 19 (95%) 21 (95%) 5 (18%) 6 (33%) 
 Negative 22 12 
P  0.94 <0.0001 <0.0001 
bFGF     
 Positive 8 (44%) 15 (71%) 19 (76%) 12 (75%) 
 Negative 10 
P  0.08 0.03 0.07 
PDGF     
 Positive 14 (70%) 10 (55%) 10 (45%) 8 (47%) 
 Negative 12 
P  0.35 0.10 0.15 
Growth in mice     
 Yes 8 (53%) 4 (27%) 12 (60%) 3 (27%) 
 No 11 
P  0.13 0.69 0.18 
Metastasisb     
 Positive 14 (74%) 15 (68%) 14 (52%) 12 (66%) 
 Negative 13 
P  0.69 0.13 0.64 
Survival (weeks) 28 88 111 117 
P  0.13 0.03 0.009 
Group AGroup BGroup CGroup D
PCNA index (%) 37.7 ± 10.4 42.1 ± 12.6 10.3 ± 6.4 11.0 ± 5.6 
Vessel density 2.7 ± 1.5 18.3 ± 12.7 3.4 ± 1.9 15.6 ± 8.5 
Apoptosis 0.31 ± 0.21 0.47 ± 0.35 0.28 ± 0.26 0.40 ± 0.34 
Pa  0.07 0.14 0.27 
VEGF     
 Positive 19 (95%) 21 (95%) 5 (18%) 6 (33%) 
 Negative 22 12 
P  0.94 <0.0001 <0.0001 
bFGF     
 Positive 8 (44%) 15 (71%) 19 (76%) 12 (75%) 
 Negative 10 
P  0.08 0.03 0.07 
PDGF     
 Positive 14 (70%) 10 (55%) 10 (45%) 8 (47%) 
 Negative 12 
P  0.35 0.10 0.15 
Growth in mice     
 Yes 8 (53%) 4 (27%) 12 (60%) 3 (27%) 
 No 11 
P  0.13 0.69 0.18 
Metastasisb     
 Positive 14 (74%) 15 (68%) 14 (52%) 12 (66%) 
 Negative 13 
P  0.69 0.13 0.64 
Survival (weeks) 28 88 111 117 
P  0.13 0.03 0.009 
a

All Ps were calculated vs. group A.

b

One case could not be defined.

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