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Table 2

Characteristics of squamous cell lung carcinomas subdivided according to PCNA index and vessel density

	Group A	Group B	Group C	Group D
PCNA index (%)	37.7 ± 10.4	42.1 ± 12.6	10.3 ± 6.4	11.0 ± 5.6
Vessel density	2.7 ± 1.5	18.3 ± 12.7	3.4 ± 1.9	15.6 ± 8.5
Apoptosis	0.31 ± 0.21	0.47 ± 0.35	0.28 ± 0.26	0.40 ± 0.34
P^a		0.07	0.14	0.27
VEGF
Positive	19 (95%)	21 (95%)	5 (18%)	6 (33%)
Negative	1	1	22	12
P		0.94	<0.0001	<0.0001
bFGF
Positive	8 (44%)	15 (71%)	19 (76%)	12 (75%)
Negative	10	6	6	4
P		0.08	0.03	0.07
PDGF
Positive	14 (70%)	10 (55%)	10 (45%)	8 (47%)
Negative	6	8	12	9
P		0.35	0.10	0.15
Growth in mice
Yes	8 (53%)	4 (27%)	12 (60%)	3 (27%)
No	7	11	8	8
P		0.13	0.69	0.18
Metastasis^b
Positive	14 (74%)	15 (68%)	14 (52%)	12 (66%)
Negative	5	7	13	6
P		0.69	0.13	0.64
Survival (weeks)	28	88	111	117
P		0.13	0.03	0.009

	Group A	Group B	Group C	Group D
PCNA index (%)	37.7 ± 10.4	42.1 ± 12.6	10.3 ± 6.4	11.0 ± 5.6
Vessel density	2.7 ± 1.5	18.3 ± 12.7	3.4 ± 1.9	15.6 ± 8.5
Apoptosis	0.31 ± 0.21	0.47 ± 0.35	0.28 ± 0.26	0.40 ± 0.34
P^a		0.07	0.14	0.27
VEGF
Positive	19 (95%)	21 (95%)	5 (18%)	6 (33%)
Negative	1	1	22	12
P		0.94	<0.0001	<0.0001
bFGF
Positive	8 (44%)	15 (71%)	19 (76%)	12 (75%)
Negative	10	6	6	4
P		0.08	0.03	0.07
PDGF
Positive	14 (70%)	10 (55%)	10 (45%)	8 (47%)
Negative	6	8	12	9
P		0.35	0.10	0.15
Growth in mice
Yes	8 (53%)	4 (27%)	12 (60%)	3 (27%)
No	7	11	8	8
P		0.13	0.69	0.18
Metastasis^b
Positive	14 (74%)	15 (68%)	14 (52%)	12 (66%)
Negative	5	7	13	6
P		0.69	0.13	0.64
Survival (weeks)	28	88	111	117
P		0.13	0.03	0.009

^a

All Ps were calculated vs. group A.

^b

One case could not be defined.