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Table 1

Clinical features and clonal relationships of paired tumors

ESCC
Patient no.HNSCC SiteIntervalaLocation in esophagusbClonal relationship (by molecular analysis)
 1 Hypopharynx Lower Not clonal 
 2 Hypopharynx Lower Not clonal 
 3 Hypopharynx 14 Upper Not clonal 
 4 Glottic larynx Middle Not clonal 
 5 Hypopharynx 16 Upper Clonal 
 6 Floor of mouth Middle Not clonal 
 7 Supraglottic larynx Middle Not clonal 
 8 Base of tongue 14 Upper Not clonal 
 9 Tonsil Lower Clonal 
10 Glottic larynx 49 Middle Not clonal 
11 Hypopharynx Lower Not clonal 
12 Floor of mouth Middle Not clonal 
13 Base of tongue Upper Not clonal 
14 Tonsil Middle Not clonal 
15 Hypopharynx Middle Not clonal 
16 Lateral tongue Upper Not clonal 
ESCC
Patient no.HNSCC SiteIntervalaLocation in esophagusbClonal relationship (by molecular analysis)
 1 Hypopharynx Lower Not clonal 
 2 Hypopharynx Lower Not clonal 
 3 Hypopharynx 14 Upper Not clonal 
 4 Glottic larynx Middle Not clonal 
 5 Hypopharynx 16 Upper Clonal 
 6 Floor of mouth Middle Not clonal 
 7 Supraglottic larynx Middle Not clonal 
 8 Base of tongue 14 Upper Not clonal 
 9 Tonsil Lower Clonal 
10 Glottic larynx 49 Middle Not clonal 
11 Hypopharynx Lower Not clonal 
12 Floor of mouth Middle Not clonal 
13 Base of tongue Upper Not clonal 
14 Tonsil Middle Not clonal 
15 Hypopharynx Middle Not clonal 
16 Lateral tongue Upper Not clonal 
a

Months between treatment of head and neck cancer and diagnosis of esophageal cancer; an interval of 0 months indicates diagnosis was made during the evaluation of head and neck cancer.

b

Upper, cervical portion extending approximately 18 cm from the upper incisor teeth; Middle, upper thoracic portion extending from the thoracic inlet to the level of the tracheal bifurcation; Lower, lower thoracic portion from the level of the tracheal bifurcation to the esophagogastric junction.

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