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Table 1

Effect of TNP-470 on the growth rate, histopathology, and vascularity of NB xenografts

Small tumors (<400 mm3)Large tumors (>400 mm3)
ControlsTNP-470-treated miceControlsTNP-470-treated mice
Mean ± SE (n)Mean ± SE (n)PMean ± SE (n)Mean ± SE (n)P
Rate of tumor growth (mm3/day) 98 ± 24 (8) 36 ± 8 (15) 0.02 220 ± 69 (5) 259 ± 47 (11) NSa 
MKI/5000 cells 154 ± 9 (7) 158 ± 21 (12) NS 152 ± 31 (3) 166 ± 12 (7) NS 
No. of blood vessels/high-power field 61 ± 6 (7) 67 ± 9 (9) NS 63 ± 3 (3) 62 ± 6 (7) NS 
Tumor necrosis (%) 12 ± 5 (7) 12 ± 4 (12) NS 18 ± 11 (3) 3 ± 1 (7) NS 
Small tumors (<400 mm3)Large tumors (>400 mm3)
ControlsTNP-470-treated miceControlsTNP-470-treated mice
Mean ± SE (n)Mean ± SE (n)PMean ± SE (n)Mean ± SE (n)P
Rate of tumor growth (mm3/day) 98 ± 24 (8) 36 ± 8 (15) 0.02 220 ± 69 (5) 259 ± 47 (11) NSa 
MKI/5000 cells 154 ± 9 (7) 158 ± 21 (12) NS 152 ± 31 (3) 166 ± 12 (7) NS 
No. of blood vessels/high-power field 61 ± 6 (7) 67 ± 9 (9) NS 63 ± 3 (3) 62 ± 6 (7) NS 
Tumor necrosis (%) 12 ± 5 (7) 12 ± 4 (12) NS 18 ± 11 (3) 3 ± 1 (7) NS 
a

NS, not significant.

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