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Table 4

Two-point HLOD scores and associated admixture coefficients (α)

The HLODs and corresponding admixture coefficients (α) are indicated at each X chromosome marker for all 153 families and after stratification according to the presence or absence of male-to-male disease transmission (male-to-male) within a pedigree. The families without male-to-male transmission were further subdivided according to whether there was early-onset prostate cancer within a family, which was defined as an average age of diagnosis ≤65 years. The bold values indicate the highest HLOD score for each category.
DXS1047DXS294DXS1205DXS1200DXS1113aDXS1193DXS1108
All families (n = 153) 0.18 (0.08) 0.01 (0.03) 0.27 (0.11) 0.00 (0.00) 0.12 (0.09) 0.15 (0.07) 0.12 (0.08) 
Male-to-male (n = 43) 0.54 (0.24) 0.82 (0.31) 1.09 (0.37) 0.00 (0.00) 0.00 (0.00) 0.03 (0.06) 0.00 (0.00) 
No male-to-male (n = 110) 0.00 (0.00) 0.00 (0.00) 0.00 (0.00) 0.00 (0.00) 0.40 (0.20) 0.12 (0.08) 0.54 (0.19) 
No male-to-male and age of diagnosis >65 years (n = 54) 0.01 (0.04) 0.00 (0.00) 0.00 (0.00) 0.00 (0.00) 0.05 (0.11) 0.00 (0.00) 0.02 (0.07) 
No male-to-male and age of diagnosis ≤65 years (n = 56) 0.00 (0.00) 0.00 (0.00) 0.00 (0.00) 0.04 (0.11) 0.45 (0.30) 0.20 (0.15) 0.73 (0.29) 
The HLODs and corresponding admixture coefficients (α) are indicated at each X chromosome marker for all 153 families and after stratification according to the presence or absence of male-to-male disease transmission (male-to-male) within a pedigree. The families without male-to-male transmission were further subdivided according to whether there was early-onset prostate cancer within a family, which was defined as an average age of diagnosis ≤65 years. The bold values indicate the highest HLOD score for each category.
DXS1047DXS294DXS1205DXS1200DXS1113aDXS1193DXS1108
All families (n = 153) 0.18 (0.08) 0.01 (0.03) 0.27 (0.11) 0.00 (0.00) 0.12 (0.09) 0.15 (0.07) 0.12 (0.08) 
Male-to-male (n = 43) 0.54 (0.24) 0.82 (0.31) 1.09 (0.37) 0.00 (0.00) 0.00 (0.00) 0.03 (0.06) 0.00 (0.00) 
No male-to-male (n = 110) 0.00 (0.00) 0.00 (0.00) 0.00 (0.00) 0.00 (0.00) 0.40 (0.20) 0.12 (0.08) 0.54 (0.19) 
No male-to-male and age of diagnosis >65 years (n = 54) 0.01 (0.04) 0.00 (0.00) 0.00 (0.00) 0.00 (0.00) 0.05 (0.11) 0.00 (0.00) 0.02 (0.07) 
No male-to-male and age of diagnosis ≤65 years (n = 56) 0.00 (0.00) 0.00 (0.00) 0.00 (0.00) 0.04 (0.11) 0.45 (0.30) 0.20 (0.15) 0.73 (0.29) 
a

In the initial report describing localization of HPCX (16), the maximum two-point LOD score for prostate cancer linkage occurred at DXS1113.

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