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Table 3

Multipoint parametric linkage results, HLOD scores and associated admixture coefficients (α)

The HLOD and corresponding admixture coefficients (α) are indicated at each X chromosome marker for all 153 families, the 140 Caucasian families, and the 11 African American families. HLOD are also provided for all families after stratification according to the presence or absence of male-to-male disease transmission (male-to-male) within a pedigree. The families without male-to-male transmission were further subdivided according to whether there was early-onset prostate cancer within a family, which was defined as an average age of diagnosis of ≤65 years. The bold values indicates the highest HLOD score for each category.
DXS1047DXS294DXS1205DXS1200DXS1113aDXS1193DXS1108
A. Family groups        
All families (n = 153) 0.22 (0.08) 0.06 (0.04) 0.00 (0.00) 0.02 (0.03) 0.04 (0.04) 0.03 (0.04) 0.00 (0.00) 
Caucasian families (n = 140) 0.28 (0.10) 0.12 (0.06) 0.01 (0.02) 0.16 (0.08) 0.22 (0.09) 0.19 (0.08) 0.08 (0.06) 
African-American families (n = 11) 0.00 (0.00) 0.00 (0.00) 0.00 (0.00) 0.00 (0.00) 0.00 (0.00) 0.00 (0.00) 0.00 (0.00) 
B. All families        
Male-to-male (n = 43) 0.62 (0.23) 0.77 (0.27) 0.37 (0.18) 0.00 (0.00) 0.00 (0.00) 0.00 (0.00) 0.00 (0.00) 
No male-to-male (n = 110) 0.00 (0.00) 0.00 (0.00) 0.00 (0.00) 0.06 (0.05) 0.11 (0.07) 0.09 (0.06) 0.15 (0.09) 
No male-to-male and age of diagnosis >65 years (n = 54) 0.06 (0.08) 0.04 (0.06) 0.00 (0.00) 0.01 (0.04) 0.00 (0.00) 0.00 (0.00) 0.00 (0.00) 
No male-to-male and age of diagnosis ≤65 years (n = 56) 0.00 (0.00) 0.00 (0.00) 0.00 (0.00) 0.05 (0.07) 0.18 (0.12) 0.15 (0.11) 0.47 (0.21) 
The HLOD and corresponding admixture coefficients (α) are indicated at each X chromosome marker for all 153 families, the 140 Caucasian families, and the 11 African American families. HLOD are also provided for all families after stratification according to the presence or absence of male-to-male disease transmission (male-to-male) within a pedigree. The families without male-to-male transmission were further subdivided according to whether there was early-onset prostate cancer within a family, which was defined as an average age of diagnosis of ≤65 years. The bold values indicates the highest HLOD score for each category.
DXS1047DXS294DXS1205DXS1200DXS1113aDXS1193DXS1108
A. Family groups        
All families (n = 153) 0.22 (0.08) 0.06 (0.04) 0.00 (0.00) 0.02 (0.03) 0.04 (0.04) 0.03 (0.04) 0.00 (0.00) 
Caucasian families (n = 140) 0.28 (0.10) 0.12 (0.06) 0.01 (0.02) 0.16 (0.08) 0.22 (0.09) 0.19 (0.08) 0.08 (0.06) 
African-American families (n = 11) 0.00 (0.00) 0.00 (0.00) 0.00 (0.00) 0.00 (0.00) 0.00 (0.00) 0.00 (0.00) 0.00 (0.00) 
B. All families        
Male-to-male (n = 43) 0.62 (0.23) 0.77 (0.27) 0.37 (0.18) 0.00 (0.00) 0.00 (0.00) 0.00 (0.00) 0.00 (0.00) 
No male-to-male (n = 110) 0.00 (0.00) 0.00 (0.00) 0.00 (0.00) 0.06 (0.05) 0.11 (0.07) 0.09 (0.06) 0.15 (0.09) 
No male-to-male and age of diagnosis >65 years (n = 54) 0.06 (0.08) 0.04 (0.06) 0.00 (0.00) 0.01 (0.04) 0.00 (0.00) 0.00 (0.00) 0.00 (0.00) 
No male-to-male and age of diagnosis ≤65 years (n = 56) 0.00 (0.00) 0.00 (0.00) 0.00 (0.00) 0.05 (0.07) 0.18 (0.12) 0.15 (0.11) 0.47 (0.21) 
a

In the initial report describing localization of HPCX (16), the maximum two-point LOD score for prostate cancer linkage occurred at DXS113.

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