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Table 1

Characteristics of the 153 families analyzed for linkage to the putative prostate cancer susceptibility gene HPCX

The clinical features of the 153 families as well as the 140 Caucasian families and the 11 African-American families are illustrated. Families were also stratified according to whether evidence of male-to-male transmission of prostate cancer was present as described in “Materials and Methods.” Early-onset families are defined as those families with an average age of prostate cancer onset of ≤65 years. The second column refers to number of families; the next four columns indicate the number of individuals.
No. of familiesNo. of affected individuals genotypedNo. of unaffected individuals genotypedAverage no. of individuals affected/family (range)Average no. of affected individuals genotyped/family (range)Average age (yr) of affected individuals genotyped (± SD)
All families 153 358 44 2.8 (2–9) 2.3 (2–5) 64.0 (± 8.4) 
African-American families 11 29 4.2 (2–9) 2.6 (2–4) 60.4 (± 10.0) 
Caucasian families 140 325 35 2.7 (2–7) 2.3 (2–5) 64.3 (± 8.2) 
Families with male-to-male transmission 43 116 24 3.8 (2–9) 2.7 (2–5) 62.7 (± 10.0) 
Families without male-to-male transmission 110 242 20 2.4 (2–7) 2.2 (2–5) 64.6 (± 7.5) 
Families without male-to-male transmission and with early-onset prostate cancer 56 124 11 2.4 (2–5) 2.2 (2–5) 60.2 (± 6.5) 
The clinical features of the 153 families as well as the 140 Caucasian families and the 11 African-American families are illustrated. Families were also stratified according to whether evidence of male-to-male transmission of prostate cancer was present as described in “Materials and Methods.” Early-onset families are defined as those families with an average age of prostate cancer onset of ≤65 years. The second column refers to number of families; the next four columns indicate the number of individuals.
No. of familiesNo. of affected individuals genotypedNo. of unaffected individuals genotypedAverage no. of individuals affected/family (range)Average no. of affected individuals genotyped/family (range)Average age (yr) of affected individuals genotyped (± SD)
All families 153 358 44 2.8 (2–9) 2.3 (2–5) 64.0 (± 8.4) 
African-American families 11 29 4.2 (2–9) 2.6 (2–4) 60.4 (± 10.0) 
Caucasian families 140 325 35 2.7 (2–7) 2.3 (2–5) 64.3 (± 8.2) 
Families with male-to-male transmission 43 116 24 3.8 (2–9) 2.7 (2–5) 62.7 (± 10.0) 
Families without male-to-male transmission 110 242 20 2.4 (2–7) 2.2 (2–5) 64.6 (± 7.5) 
Families without male-to-male transmission and with early-onset prostate cancer 56 124 11 2.4 (2–5) 2.2 (2–5) 60.2 (± 6.5) 
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