Drugs with positive food effect with meals and black box safety warnings
| Drugs with positive food effects* and black box safety warnings . | Therapeutic area . | Black box warning . | Risk of QT prolongation . | AUC ratio (fed/fasted) . | Warning regarding food effect . | Label . |
|---|---|---|---|---|---|---|
| Ziprasidone HCl | Non-oncology | Elderly with dementia related psychosis with increased risk of death | Yes | 2 | No | Fed |
| Lapatinib | Oncology | Hepatotoxicity | Yes | 4.1 | No | Fasted |
| Nilotinib | Oncology | QT prolongation | Yes | 1.74 | Yes | Fasted |
| Drugs with positive food effects* and black box safety warnings . | Therapeutic area . | Black box warning . | Risk of QT prolongation . | AUC ratio (fed/fasted) . | Warning regarding food effect . | Label . |
|---|---|---|---|---|---|---|
| Ziprasidone HCl | Non-oncology | Elderly with dementia related psychosis with increased risk of death | Yes | 2 | No | Fed |
| Lapatinib | Oncology | Hepatotoxicity | Yes | 4.1 | No | Fasted |
| Nilotinib | Oncology | QT prolongation | Yes | 1.74 | Yes | Fasted |
*Positive food effect: increase of AUC by at least 25% with meals.