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Table 2.

Drugs with positive food effect with meals and black box safety warnings

Drugs with positive food effects* and black box safety warningsTherapeutic areaBlack box warningRisk of QT prolongationAUC ratio (fed/fasted)Warning regarding food effectLabel
Ziprasidone HCl Non-oncology Elderly with dementia related psychosis with increased risk of death Yes No Fed 
Lapatinib Oncology Hepatotoxicity Yes 4.1 No Fasted 
Nilotinib Oncology QT prolongation Yes 1.74 Yes Fasted 
Drugs with positive food effects* and black box safety warningsTherapeutic areaBlack box warningRisk of QT prolongationAUC ratio (fed/fasted)Warning regarding food effectLabel
Ziprasidone HCl Non-oncology Elderly with dementia related psychosis with increased risk of death Yes No Fed 
Lapatinib Oncology Hepatotoxicity Yes 4.1 No Fasted 
Nilotinib Oncology QT prolongation Yes 1.74 Yes Fasted 

*Positive food effect: increase of AUC by at least 25% with meals.

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