Summary of food effects and labels of 23 NMEs that were approved by the FDA from January 2000 to May 2009
| Name . | AUC ratio (fed/fasted) . | CV fasted . | CV fed . | CV fed-CV fasted . | Label . |
|---|---|---|---|---|---|
| Lapatinib | 4.1 | 68% | 52% | −16% | Fasted |
| Posaconazole | 3.6 | 36% | 41% | 5% | Fed |
| Erlotinib | 2.09 | 36% | 18% | −18% | Fasted |
| Alfuzosin HCl | 2 | 69% | 40% | −29% | Fed |
| Ziprasidone HCl | 2 | 44% | 22% | −22% | Fed |
| Nitazoxanide | 1.9 | 35% | 37% | 2% | Fed |
| Rifaximin | 1.89 | 51% | 26% | −25% | Either |
| Nilotinib | 1.74 | 35% | 30% | −5% | Fasted |
| Cinacalcet | 1.68 | 60% | 46% | −14% | Fed |
| Deferasirox | 1.62 | 36% | 31% | −5% | Fasted |
| Etravirine | 1.54 | 111% | 80% | −31% | Fed |
| Vorinostat | 1.38 | 43% | 32% | −11% | Fed |
| Rufinamide | 1.34 | 30% | 28% | −2% | Fed |
| Gefitinib | 1.33 | 55% | 40% | −15% | Either |
| Darunavir | 1.3 | 15-35% | 15-35% | 0% | Fed |
| Tapentadol | 1.26 | 36% | 29% | −7% | Either |
| Rasagiline | 0.8 | 30% | 32% | 2% | Either |
| Voriconazole | 0.76 | 125% | 150% | 25% | Fasted |
| Sorafenib | 0.69 | 36% | 53% | 17% | Fasted |
| Sodium oxybate | 0.65 | 38% | 42% | 4% | Fasted |
| Tegaserod maleate | 0.42 | 26% | 32% | 6% | Fasted |
| Eltrombopag | 0.41 | 28% | 27% | −1% | Fasted |
| Aliskiren | 0.3 | 49% | 60% | 11% | Fasted |
| Name . | AUC ratio (fed/fasted) . | CV fasted . | CV fed . | CV fed-CV fasted . | Label . |
|---|---|---|---|---|---|
| Lapatinib | 4.1 | 68% | 52% | −16% | Fasted |
| Posaconazole | 3.6 | 36% | 41% | 5% | Fed |
| Erlotinib | 2.09 | 36% | 18% | −18% | Fasted |
| Alfuzosin HCl | 2 | 69% | 40% | −29% | Fed |
| Ziprasidone HCl | 2 | 44% | 22% | −22% | Fed |
| Nitazoxanide | 1.9 | 35% | 37% | 2% | Fed |
| Rifaximin | 1.89 | 51% | 26% | −25% | Either |
| Nilotinib | 1.74 | 35% | 30% | −5% | Fasted |
| Cinacalcet | 1.68 | 60% | 46% | −14% | Fed |
| Deferasirox | 1.62 | 36% | 31% | −5% | Fasted |
| Etravirine | 1.54 | 111% | 80% | −31% | Fed |
| Vorinostat | 1.38 | 43% | 32% | −11% | Fed |
| Rufinamide | 1.34 | 30% | 28% | −2% | Fed |
| Gefitinib | 1.33 | 55% | 40% | −15% | Either |
| Darunavir | 1.3 | 15-35% | 15-35% | 0% | Fed |
| Tapentadol | 1.26 | 36% | 29% | −7% | Either |
| Rasagiline | 0.8 | 30% | 32% | 2% | Either |
| Voriconazole | 0.76 | 125% | 150% | 25% | Fasted |
| Sorafenib | 0.69 | 36% | 53% | 17% | Fasted |
| Sodium oxybate | 0.65 | 38% | 42% | 4% | Fasted |
| Tegaserod maleate | 0.42 | 26% | 32% | 6% | Fasted |
| Eltrombopag | 0.41 | 28% | 27% | −1% | Fasted |
| Aliskiren | 0.3 | 49% | 60% | 11% | Fasted |
NOTE: NMEs with both AUC and CV data available were included.