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Table 5.

Cox regression analysis to determine prognostic significance of p53 codon 72 phenotypes

Prognostic variablesIndicator of poor prognosisHazard ratio* (95% confidence intervals)P
African American patients    
Codon 72 polymorphism    
    Pro/Pro vs. Arg/Arg or Arg/Pro Pro/Pro 2.15 (1.02-4.53) 0.045 
p53 status    
    Mutated vs. wild-type Mutated 2.30 (1.19-4.45) 0.014 
Tumor location    
    Proximal colon vs. Rectum Proximal colon 2.18 (1.24-3.82) 0.007 
    Distal colon vs. Rectum Distal colon 1.27 (0.42-3.92) 0.674 
Tumor stage    
    II vs. I II 3.77 (0.85-16.79) 0.081 
    III vs. I III 17.17 (1.65-31.21) 0.008 
    IV vs. I IV 27.46 (5.88-128.28) <0.0001 
Tumor size    
    >5 cm vs. ≤5 cm >5 cm 0.41 (0.23-0.74) 0.003 
Caucasian patients    
Codon 72 polymorphism    
    Pro/Pro vs. Arg/Arg or Arg/Pro Pro/Pro 1.60 (0.69-3.18) 0.277 
p53 status    
    Mutated vs. wild-type Mutated 1.55 (1.04-2.32) 0.032 
Tumor stage    
    II vs. I II 1.63 (0.74-3.59) 0.229 
    III vs. I III 4.10 (1.92- 8.77) 0.0003 
    IV vs. I IV 10.71 (4.72-24.29) <0.0001 
Prognostic variablesIndicator of poor prognosisHazard ratio* (95% confidence intervals)P
African American patients    
Codon 72 polymorphism    
    Pro/Pro vs. Arg/Arg or Arg/Pro Pro/Pro 2.15 (1.02-4.53) 0.045 
p53 status    
    Mutated vs. wild-type Mutated 2.30 (1.19-4.45) 0.014 
Tumor location    
    Proximal colon vs. Rectum Proximal colon 2.18 (1.24-3.82) 0.007 
    Distal colon vs. Rectum Distal colon 1.27 (0.42-3.92) 0.674 
Tumor stage    
    II vs. I II 3.77 (0.85-16.79) 0.081 
    III vs. I III 17.17 (1.65-31.21) 0.008 
    IV vs. I IV 27.46 (5.88-128.28) <0.0001 
Tumor size    
    >5 cm vs. ≤5 cm >5 cm 0.41 (0.23-0.74) 0.003 
Caucasian patients    
Codon 72 polymorphism    
    Pro/Pro vs. Arg/Arg or Arg/Pro Pro/Pro 1.60 (0.69-3.18) 0.277 
p53 status    
    Mutated vs. wild-type Mutated 1.55 (1.04-2.32) 0.032 
Tumor stage    
    II vs. I II 1.63 (0.74-3.59) 0.229 
    III vs. I III 4.10 (1.92- 8.77) 0.0003 
    IV vs. I IV 10.71 (4.72-24.29) <0.0001 
*

Adjusted for the p53 codon 72 polymorphism, p53 gene mutations, age, gender, and TNM tumor stage, tumor location within the colorectum, tumor grade, and tumor size.

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