Skip to Main Content
Table 2.

Clinicopathologic and molecular features

VariableAfrican Americans,* n = 137 (%)Caucasians,n= 236 (%)χ2P
Age group (y)    
    <65 56 (41) 102 (43) 0.66 
    ≥65 81 (59) 134 (57)  
Gender    
    Female 60 (44) 86 (36) 0.16 
    Male 77 (56) 150 (64)  
Tumor location    
    Proximal colon 80 (58) 101 (43) 0.005 
    Distal colon 41 (30) 79 (34)  
    Rectum 16 (12) 55 (23)  
Depth of tumor invasion    
    pTx 1 (<1) 0.79 
    pT1 4 (2) 6 (3)  
    pT2 20 (15) 42 (18)  
    pT3 86 (63) 135 (58)  
    pT4 27 (20) 50 (21)  
Nodal status    
    Nx 1 (<1) 0.64 
    N0 73 (53) 131 (56)  
    N1-3 64 (47) 102 (44)  
Distant metastasis    
    M0 118 (86) 203 (87) 0.86 
    M1 19 (14) 31 (13)  
Tumor stage    
    I 17 (12) 33 (14) 0.96 
    II 53 (39) 92 (39)  
    III 48 (35) 78 (34)  
    IV 19 (14) 31 (13)  
Tumor grade    
    Low 103 (76) 179 (78) 0.65 
    High 33 (24) 51 (22)  
Tumor size (cm)    
    ≤5 73 (53) 132 (59) 0.48 
    >5 62 (47) 96 (41)  
p53 status    
    Wild-type 69 (50) 109 (46) 0.44 
    Mutated 68 (50) 127 (54)  
p53 mutation type    
    Disruptive 31 (46) 51 (40) 0.46 
    Nondisruptive 37 (54) 76 (60)  
p53 codon 72 phenotypes    
    Arg/Arg 26 (19) 85 (36) 0.002 
    Arg/Pro 87 (64) 134 (57)  
    Pro/Pro 24 (17) 17 (7)  
Vital status at the end of follow-up§    
    Alive 36 (28) 64 (29) 0.98 
    Died due to CRC 61 (48) 104 (47)  
    Died due to other causes 31 (24) 52 (24)  
VariableAfrican Americans,* n = 137 (%)Caucasians,n= 236 (%)χ2P
Age group (y)    
    <65 56 (41) 102 (43) 0.66 
    ≥65 81 (59) 134 (57)  
Gender    
    Female 60 (44) 86 (36) 0.16 
    Male 77 (56) 150 (64)  
Tumor location    
    Proximal colon 80 (58) 101 (43) 0.005 
    Distal colon 41 (30) 79 (34)  
    Rectum 16 (12) 55 (23)  
Depth of tumor invasion    
    pTx 1 (<1) 0.79 
    pT1 4 (2) 6 (3)  
    pT2 20 (15) 42 (18)  
    pT3 86 (63) 135 (58)  
    pT4 27 (20) 50 (21)  
Nodal status    
    Nx 1 (<1) 0.64 
    N0 73 (53) 131 (56)  
    N1-3 64 (47) 102 (44)  
Distant metastasis    
    M0 118 (86) 203 (87) 0.86 
    M1 19 (14) 31 (13)  
Tumor stage    
    I 17 (12) 33 (14) 0.96 
    II 53 (39) 92 (39)  
    III 48 (35) 78 (34)  
    IV 19 (14) 31 (13)  
Tumor grade    
    Low 103 (76) 179 (78) 0.65 
    High 33 (24) 51 (22)  
Tumor size (cm)    
    ≤5 73 (53) 132 (59) 0.48 
    >5 62 (47) 96 (41)  
p53 status    
    Wild-type 69 (50) 109 (46) 0.44 
    Mutated 68 (50) 127 (54)  
p53 mutation type    
    Disruptive 31 (46) 51 (40) 0.46 
    Nondisruptive 37 (54) 76 (60)  
p53 codon 72 phenotypes    
    Arg/Arg 26 (19) 85 (36) 0.002 
    Arg/Pro 87 (64) 134 (57)  
    Pro/Pro 24 (17) 17 (7)  
Vital status at the end of follow-up§    
    Alive 36 (28) 64 (29) 0.98 
    Died due to CRC 61 (48) 104 (47)  
    Died due to other causes 31 (24) 52 (24)  

Abbreviations: n, total number of cases; CRC, colorectal cancer.

*

Information on tumor grade for one case and tumor size for two cases was not available for African Americans.

Information on tumor location for one case; pT, pN and M for two cases; tumor stage for two cases; tumor grade for six cases; and tumor size for eight cases was not available for Caucasians.

p53 mutation that introduces an amino acid that disrupts functional domains of p53.

§

As described in Materials & Methods, 9 African American and 16 Caucasian patients were lost to follow-up.

Close Modal

or Create an Account

Close Modal
Close Modal