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Table 1.

Biodistribution of radioiodinated-2B3 minibody in different PSCA-positive tumor bearing mice at 21 h postinjection

TissueLAPC-9 124 I (n = 12)LNCaP-PSCA 131 I (n = 4)PC-3-PSCA 124 I (n = 4)LAPC-9 AI 124 I (n = 4)
Positive tumor (T) 5.2 ± 1.6 9.3 ± 2.3 2.4 ± 0.2 2.5 ± 1.0 
Negative tumor (PC-3) 2.6 ± 0.2* ND 0.7 ± 0.3 ND 
Liver 1.3 ± 0.3 1.1 ± 0.3§ 0.5 ± 0.1 0.9 ± 0.2 
Spleen 1.5 ± 0.5 0.7 ± 0.4§ 0.6 ± 0.2 0.8 ± 0.1 
Kidney 1.9 ± 0.5 2.0 ± 0.4§ 0.8 ± 0.2 1.3 ± 0.2 
Lung 3.4 ± 1.0 2.1 ± 0.3§ 1.2 ± 0.5 2.1 ± 0.4 
Blood 4.9 ± 1.3 3.3 ± 1.6§ 2.3 ± 0.6 3.4 ± 0.5 
Carcass 1.2 ± 0.1 ND ND 0.6 ± 0.2 
Ratios     
    T/blood 1.1 2.8 1.0 0.7 
    T/liver 4.0 8.5 4.8 2.8 
    T/kidney 2.7 4.7 3.0 1.9 
    T/neg tumor 2.0 ND 3.4 ND 
Tumor weight (mg)     
    PSCA-positive 910 ± 740 160 ± 40 150 ± 60 1,640 ± 210 
    PC-3 300 ± 130 ND 181 ± 64 ND 
TissueLAPC-9 124 I (n = 12)LNCaP-PSCA 131 I (n = 4)PC-3-PSCA 124 I (n = 4)LAPC-9 AI 124 I (n = 4)
Positive tumor (T) 5.2 ± 1.6 9.3 ± 2.3 2.4 ± 0.2 2.5 ± 1.0 
Negative tumor (PC-3) 2.6 ± 0.2* ND 0.7 ± 0.3 ND 
Liver 1.3 ± 0.3 1.1 ± 0.3§ 0.5 ± 0.1 0.9 ± 0.2 
Spleen 1.5 ± 0.5 0.7 ± 0.4§ 0.6 ± 0.2 0.8 ± 0.1 
Kidney 1.9 ± 0.5 2.0 ± 0.4§ 0.8 ± 0.2 1.3 ± 0.2 
Lung 3.4 ± 1.0 2.1 ± 0.3§ 1.2 ± 0.5 2.1 ± 0.4 
Blood 4.9 ± 1.3 3.3 ± 1.6§ 2.3 ± 0.6 3.4 ± 0.5 
Carcass 1.2 ± 0.1 ND ND 0.6 ± 0.2 
Ratios     
    T/blood 1.1 2.8 1.0 0.7 
    T/liver 4.0 8.5 4.8 2.8 
    T/kidney 2.7 4.7 3.0 1.9 
    T/neg tumor 2.0 ND 3.4 ND 
Tumor weight (mg)     
    PSCA-positive 910 ± 740 160 ± 40 150 ± 60 1,640 ± 210 
    PC-3 300 ± 130 ND 181 ± 64 ND 

NOTE: Numbers represent mean uptake expressed in %ID/g ± SD.

Abbreviation: ND, not determined.

*

n = 4.

Significantly different from LAPC-9 uptake (P < 0.01).

Significantly different from PC-3-PSCA uptake (P < 0.01).

§

Significantly different from LNCaP-PSCA uptake (P < 0.01).

n = 8.

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