American Association for Cancer Research

Table 1.

Biodistribution of radioiodinated-2B3 minibody in different PSCA-positive tumor bearing mice at 21 h postinjection

Tissue	LAPC-9 ¹²⁴ I (n = 12)	LNCaP-PSCA ¹³¹ I (n = 4)	PC-3-PSCA ¹²⁴ I (n = 4)	LAPC-9 AI ¹²⁴ I (n = 4)
Positive tumor (T)	5.2 ± 1.6	9.3 ± 2.3	2.4 ± 0.2	2.5 ± 1.0
Negative tumor (PC-3)	2.6 ± 0.2*^†	ND	0.7 ± 0.3^‡	ND
Liver	1.3 ± 0.3^†	1.1 ± 0.3^§	0.5 ± 0.1^‡	0.9 ± 0.2
Spleen	1.5 ± 0.5^†	0.7 ± 0.4^§	0.6 ± 0.2^‡	0.8 ± 0.1
Kidney	1.9 ± 0.5^†	2.0 ± 0.4^§	0.8 ± 0.2^‡	1.3 ± 0.2
Lung	3.4 ± 1.0^†	2.1 ± 0.3^§	1.2 ± 0.5	2.1 ± 0.4
Blood	4.9 ± 1.3	3.3 ± 1.6^§	2.3 ± 0.6	3.4 ± 0.5
Carcass	1.2 ± 0.1^†^∥	ND	ND	0.6 ± 0.2
Ratios
T/blood	1.1	2.8	1.0	0.7
T/liver	4.0	8.5	4.8	2.8
T/kidney	2.7	4.7	3.0	1.9
T/neg tumor	2.0	ND	3.4	ND
Tumor weight (mg)
PSCA-positive	910 ± 740	160 ± 40	150 ± 60	1,640 ± 210
PC-3	300 ± 130	ND	181 ± 64	ND

Tissue	LAPC-9 ¹²⁴ I (n = 12)	LNCaP-PSCA ¹³¹ I (n = 4)	PC-3-PSCA ¹²⁴ I (n = 4)	LAPC-9 AI ¹²⁴ I (n = 4)
Positive tumor (T)	5.2 ± 1.6	9.3 ± 2.3	2.4 ± 0.2	2.5 ± 1.0
Negative tumor (PC-3)	2.6 ± 0.2*^†	ND	0.7 ± 0.3^‡	ND
Liver	1.3 ± 0.3^†	1.1 ± 0.3^§	0.5 ± 0.1^‡	0.9 ± 0.2
Spleen	1.5 ± 0.5^†	0.7 ± 0.4^§	0.6 ± 0.2^‡	0.8 ± 0.1
Kidney	1.9 ± 0.5^†	2.0 ± 0.4^§	0.8 ± 0.2^‡	1.3 ± 0.2
Lung	3.4 ± 1.0^†	2.1 ± 0.3^§	1.2 ± 0.5	2.1 ± 0.4
Blood	4.9 ± 1.3	3.3 ± 1.6^§	2.3 ± 0.6	3.4 ± 0.5
Carcass	1.2 ± 0.1^†^∥	ND	ND	0.6 ± 0.2
Ratios
T/blood	1.1	2.8	1.0	0.7
T/liver	4.0	8.5	4.8	2.8
T/kidney	2.7	4.7	3.0	1.9
T/neg tumor	2.0	ND	3.4	ND
Tumor weight (mg)
PSCA-positive	910 ± 740	160 ± 40	150 ± 60	1,640 ± 210
PC-3	300 ± 130	ND	181 ± 64	ND

NOTE: Numbers represent mean uptake expressed in %ID/g ± SD.

Abbreviation: ND, not determined.

n = 4.

Significantly different from LAPC-9 uptake (P < 0.01).

Significantly different from PC-3-PSCA uptake (P < 0.01).

Significantly different from LNCaP-PSCA uptake (P < 0.01).

n = 8.