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Table 2.

Prognostic factors

Univariate analysis
Multiple models
All available cases
n = 191
n = 93
VariablenHR (95% CI)Sig.HR (95% CI)Sig.HR (95% CI)Sig.
Male sex 324 1.0 (0.7-1.3) P = 0.909 1.0 (0.6-1.5) P = 0.864 0.9 (0.4-2.0) P = 0.858 
No macroscopically radical surgery 305 4.8 (3.3-7.0) P < 0.001 2.5 (1.2-4.9) P = 0.010 8.4 (0.9-75) P = 0.057 
WHO classification 240       
    Well-differentiated carcinoma  4.4 (2.4-8.0) P < 0.001 1.2 (0.4-3.5) P = 0.700   
    Poorly differentiated carcinoma  14.9 (7.1-31.4) P < 0.001 9.9 (2.9-34) P < 0.001   
    Nonfunctioning tumor 324 1.6 (1.2-2.2) P = 0.004 1.0 (0.6-1.6) P = 0.937 1.0 (0.3-3.3) P = 0.992 
Ki67 >2% 115 6.0 (2.7-13.6) P < 0.001   5.2 (1.8-15) P = 0.002 
CgA ≥ 3 × UNL 137 2.5 (1.5-4.2) P = 0.001     
BMI (kg/m2) 155       
    20-24.9  1.4 (0.9-2.2) P = 0.202     
    <20  2.5 (1.3-4.7) P = 0.007     
Primary referral 323 1.4 (1.0-1.9) P = 0.023 1.9 (1.2-3.0) P = 0.007 1.7 (0.8-3.6) P = 0.200 
Sporadic tumor 320 2.7 (1.7-4.3) P < 0.001 1.0 (0.4-2.4) P = 0.953 1.2 (0.1-21) P = 0.917 
Stage 302       
    IIa  0.6 (0.2-1.8) P = 0.338 0.5 (0.1-2.8) P = 0.444   
    IIb  1.8 (0.7-4.8) P = 0.250 2.3 (0.5-11) P = 0.270   
    IIIa  4.6 (1.8-12.0) P = 0.002 3.5 (0.7-19) P = 0.142   
    IIIb  2.6 (1.2-5.5) P = 0.011 2.2 (0.5-9.2) P = 0.290   
    IV  6.5 (3.5-12.0) P < 0.001 5.9 (1.3-26) P = 0.020   
Size (cm) 260       
    3-3.9  3.1 (1.7-5.7) P < 0.001 1.0 (0.4-2.7) P = 0.941 0.2 (0.0-1.3) P = 0.087 
    4-4.9  2.2 (1.2-4.2) P = 0.014 0.9 (0.3-2.3) P = 0.832 0.3 (0.1-0.4) P = 0.121 
    5-9.9  3.6 (2.3-5.8) P < 0.001 1.6 (0.7-3.7) P = 0.233 0.6 (0.1-2.8) P = 0.647 
    ≥10  3.8 (1.9-7.6) P < 0.001 2.6 (1.0-7.1) P = 0.063 0.6 (0.1-3.1) P = 0.575 
Univariate analysis
Multiple models
All available cases
n = 191
n = 93
VariablenHR (95% CI)Sig.HR (95% CI)Sig.HR (95% CI)Sig.
Male sex 324 1.0 (0.7-1.3) P = 0.909 1.0 (0.6-1.5) P = 0.864 0.9 (0.4-2.0) P = 0.858 
No macroscopically radical surgery 305 4.8 (3.3-7.0) P < 0.001 2.5 (1.2-4.9) P = 0.010 8.4 (0.9-75) P = 0.057 
WHO classification 240       
    Well-differentiated carcinoma  4.4 (2.4-8.0) P < 0.001 1.2 (0.4-3.5) P = 0.700   
    Poorly differentiated carcinoma  14.9 (7.1-31.4) P < 0.001 9.9 (2.9-34) P < 0.001   
    Nonfunctioning tumor 324 1.6 (1.2-2.2) P = 0.004 1.0 (0.6-1.6) P = 0.937 1.0 (0.3-3.3) P = 0.992 
Ki67 >2% 115 6.0 (2.7-13.6) P < 0.001   5.2 (1.8-15) P = 0.002 
CgA ≥ 3 × UNL 137 2.5 (1.5-4.2) P = 0.001     
BMI (kg/m2) 155       
    20-24.9  1.4 (0.9-2.2) P = 0.202     
    <20  2.5 (1.3-4.7) P = 0.007     
Primary referral 323 1.4 (1.0-1.9) P = 0.023 1.9 (1.2-3.0) P = 0.007 1.7 (0.8-3.6) P = 0.200 
Sporadic tumor 320 2.7 (1.7-4.3) P < 0.001 1.0 (0.4-2.4) P = 0.953 1.2 (0.1-21) P = 0.917 
Stage 302       
    IIa  0.6 (0.2-1.8) P = 0.338 0.5 (0.1-2.8) P = 0.444   
    IIb  1.8 (0.7-4.8) P = 0.250 2.3 (0.5-11) P = 0.270   
    IIIa  4.6 (1.8-12.0) P = 0.002 3.5 (0.7-19) P = 0.142   
    IIIb  2.6 (1.2-5.5) P = 0.011 2.2 (0.5-9.2) P = 0.290   
    IV  6.5 (3.5-12.0) P < 0.001 5.9 (1.3-26) P = 0.020   
Size (cm) 260       
    3-3.9  3.1 (1.7-5.7) P < 0.001 1.0 (0.4-2.7) P = 0.941 0.2 (0.0-1.3) P = 0.087 
    4-4.9  2.2 (1.2-4.2) P = 0.014 0.9 (0.3-2.3) P = 0.832 0.3 (0.1-0.4) P = 0.121 
    5-9.9  3.6 (2.3-5.8) P < 0.001 1.6 (0.7-3.7) P = 0.233 0.6 (0.1-2.8) P = 0.647 
    ≥10  3.8 (1.9-7.6) P < 0.001 2.6 (1.0-7.1) P = 0.063 0.6 (0.1-3.1) P = 0.575 
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