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Table 1.

Patients demographics and main pathologic features

CharacteristicsNo. of patients; n = 109
Age (y)  
    <40 22 (20%) 
    ≥40 87 (80%) 
Sex  
    Male 47 (43%) 
    Female 62 (57%) 
Von Hippel-Lindau disease  
    Present 12 (11%) 
    Absent 97 (89%) 
Multiple endocrine neoplasia type 1 disease  
    Present 5 (5%) 
    Absent 104 (95%) 
Functional syndrome  
    Present 24 (22%) 
    Absent 85 (78%) 
Size  
    ≤20 mm 37 (34%) 
    >20 mm 72 (66%) 
Classification according to WHO 2000  
    Benign endocrine tumors 31 (28%) 
    Endocrine tumors of uncertain behavior 27 (25%) 
    Well-differentiated endocrine carcinomas 51 (47%) 
Staging according to TNM 2006*  
    Stage 1 31(28%) 
    Stage 2 24 (22%) 
    Stage 3 28 (26%) 
    Stage 4 26 (24%) 
Grading according to TNM 2006*  
    Grade G1 41 (38%) 
    Grade G2 63 (58%) 
    Grade G3 5 (4%) 
Necrosis  
    No necrosis 97 (89%) 
    Presence of necrosis 12 (11%) 
Ki-67 (%)  
    ≤2 55 (50%) 
    >2 54 (50%) 
Lymph node metastasis  
    Absent 67 (61%) 
    Present 42 (39%) 
Liver metastasis  
    Absent 83 (76%) 
    Present 26 (24%) 
Duration of follow-up (mo)  
    Median 22 
    Range 1-130 
    Lost to follow-up 
    Death 
CharacteristicsNo. of patients; n = 109
Age (y)  
    <40 22 (20%) 
    ≥40 87 (80%) 
Sex  
    Male 47 (43%) 
    Female 62 (57%) 
Von Hippel-Lindau disease  
    Present 12 (11%) 
    Absent 97 (89%) 
Multiple endocrine neoplasia type 1 disease  
    Present 5 (5%) 
    Absent 104 (95%) 
Functional syndrome  
    Present 24 (22%) 
    Absent 85 (78%) 
Size  
    ≤20 mm 37 (34%) 
    >20 mm 72 (66%) 
Classification according to WHO 2000  
    Benign endocrine tumors 31 (28%) 
    Endocrine tumors of uncertain behavior 27 (25%) 
    Well-differentiated endocrine carcinomas 51 (47%) 
Staging according to TNM 2006*  
    Stage 1 31(28%) 
    Stage 2 24 (22%) 
    Stage 3 28 (26%) 
    Stage 4 26 (24%) 
Grading according to TNM 2006*  
    Grade G1 41 (38%) 
    Grade G2 63 (58%) 
    Grade G3 5 (4%) 
Necrosis  
    No necrosis 97 (89%) 
    Presence of necrosis 12 (11%) 
Ki-67 (%)  
    ≤2 55 (50%) 
    >2 54 (50%) 
Lymph node metastasis  
    Absent 67 (61%) 
    Present 42 (39%) 
Liver metastasis  
    Absent 83 (76%) 
    Present 26 (24%) 
Duration of follow-up (mo)  
    Median 22 
    Range 1-130 
    Lost to follow-up 
    Death 
*

Proposed classification, ref. 17.

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