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Table 2.

Number of dose-limiting toxicities observed in each cohort (drug-related, first course)

5-AZA dose (mg/m2)No. of patientsGrade 3 or 4 toxicitiesNo. of patients
20 6   
25 6   
37.5 8 Neutropenic fever 1 
47 7   
59 6   
75 16 Neutropenic fever 3 
94 6 Neutropenic fever 2 
  Thrombocytopenia 1 
Total 55  7 
5-AZA dose (mg/m2)No. of patientsGrade 3 or 4 toxicitiesNo. of patients
20 6   
25 6   
37.5 8 Neutropenic fever 1 
47 7   
59 6   
75 16 Neutropenic fever 3 
94 6 Neutropenic fever 2 
  Thrombocytopenia 1 
Total 55  7 
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