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Table 2.

Number of dose-limiting toxicities observed in each cohort (drug-related, first course)

5-AZA dose (mg/m2)No. of patientsGrade 3 or 4 toxicitiesNo. of patients
20   
25   
37.5 Neutropenic fever 
47   
59   
75 16 Neutropenic fever 
94 Neutropenic fever 
  Thrombocytopenia 
Total 55  
5-AZA dose (mg/m2)No. of patientsGrade 3 or 4 toxicitiesNo. of patients
20   
25   
37.5 Neutropenic fever 
47   
59   
75 16 Neutropenic fever 
94 Neutropenic fever 
  Thrombocytopenia 
Total 55  
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