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Table 2.

Increased antitumor activity of vaccine plus docetaxel

TreatmentnTumor volume (day 37; mm3)P = (vs:)
NoneDocetaxelVaccineVaccine + docetaxel
None 13 2038 ± 232 — 0.76 0.12 0.003 
Docetaxel 14 2199 ± 409 0.76 — 0.197 0.030 
Vaccine 13 1575 ± 107 0.12 0.197 — 0.036 
Vaccine + docetaxel 15 1206 ± 85 0.003 0.030 0.036 — 
TreatmentnTumor volume (day 37; mm3)P = (vs:)
NoneDocetaxelVaccineVaccine + docetaxel
None 13 2038 ± 232 — 0.76 0.12 0.003 
Docetaxel 14 2199 ± 409 0.76 — 0.197 0.030 
Vaccine 13 1575 ± 107 0.12 0.197 — 0.036 
Vaccine + docetaxel 15 1206 ± 85 0.003 0.030 0.036 — 

NOTE: CEA-Tg mice were implanted s.c. with MC38-CEA+ tumors on day 0. Mice were either not treated (none), treated with docetaxel alone, vaccine alone, or first vaccinated and then treated with docetaxel (Fig. 5). Shown is average group tumor volumes at day 37. Bold numbers indicate statistical significance (P < 0.05).

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