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Table 3.

Analysis of association between MMPs and the risk of lymph node metastasis by population group

GenotypeMixed ethnicity
Caucasian
No. patientsNode-negative, n (%)Node-positive, n (%)Crude OR [95% CI] (P)Adjusted* OR [95% CI] (P)No. patientsNode-negative, n (%)Node-positive, n (%)Crude OR [95% CI] (P)Adjusted* OR [95% CI] (P)
MMP-1           
    1G/1G 52 35 (27.8) 17 (18.5) 1.0 1.0 38 26 (29.5) 12 (23) 1.0 1.0 
    1G/2G 101 64 (50.8) 37 (40.2) 1.2 [0.6-2.4] (0.63) 1.2 [0.5-2.6] (0.75) 63 43 (48.9) 20 (38.5) 1.01 [0.3-2.4] (0.98) 0.9 [0.4-2.3] (0.83) 
    2G/2G 65 27 (21.4) 38 (41.3) 2.9 [1.4-6.2] (0.01) 3.9 [1.7-9.4] (0.001) 39 19 (21.6) 20 (38.5) 2.3 [0.9-5.8] (0.08) 2.6 [1.0-6.9] (0.06) 
MMP-3           
    5A/5A 49 26 (20.9) 23 (25.5) 1.0 1.0 39 23 (27) 16 (32) 1.0 1.0 
    5A/6A 114 70 (56.5) 44 (49) 0.7 [0.4-1.4] (0.32) 1.1 [0.5-2.3] (0.88) 73 44 (51.8) 29 (58) 1.0 [0.4-2.1] (0.89) 1.1 [0.5-2.4] (0.92) 
    6A/6A 51 28 (22.6) 23 (25.5) 0.9 [0.4-2.0] (0.85) 0.8 [0.3-2.0] (0.63) 23 18 (21.2) 5 (10) 0.4 [0.1-1.3] (0.40) 0.3 [0.1-1.2] (0.10) 
MMP-7           
    A/A 70 37 (31.4) 33 (37.9) 1.0 1.0 47 30 (37) 17 (34.7) 1.0 1.0 
    A/G 96 60 (50.8) 36 (41.4) 0.7 [0.4-1.3] (0.21) 0.6 [0.3-1.2] (0.17) 59 39 (48) 20 (42.5) 0.9 [0.4-2.0] (0.81) 0.7 [0.3-1.7] (0.54) 
    G/G 39 21 (17.8) 18 (20.7) 1.0 [0.4-2.1] (0.92) 0.7 [0.3-1.7] (0.40) 24 12 (15) 12 (22.8) 1.8 [0.7-4.8] (0.26) 1.3 [0.4-3.7] (0.65) 
MMP-9           
    C/C 167 105 (93.7) 62 (81.6) 1.0 1.0 109 74 (97.3) 35 (81.3) 1.0 1.0 
    C/T 21 7 (6.3) 14 (18.4) 3.4 [1.3-8.9] (0.01) 3.6 [1.2. 11.1] (0.001) 10 2 (2.7) 8 (19.7) 8.5 [1.7-41.9] (0.01) 9.1 [1.7-48.4] (0.01) 
MMP-12           
    A/A 168 98 (80.3) 70 (82.4) 1.0 1.0 107 67 (80.7) 40 (83.3) 1.0 1.0 
    A/G 39 24 (19.7) 15 (17.6) 0.9 [0.4-1.8] (71) 1.2 [0.5-2.8] (0.63) 24 16 (19.3) 8 (16.7) 0.8 [0.3-2.1] (0.71) 1.1 [0.4-2.8] (0.91) 
MMP-13           
    A/A 105 62 (54.9) 43 (53.8) 1.0 1.0 71 44 (56.4) 27 (61.4) 1.0 1.0 
    A/G 83 47 (41.6) 36 (45) 1.1 [0.6-2.0] (0.74) 1.2 [0.6-2.3] (0.62) 49 32 (41) 17 (38.6) 0.8 [0.4-1.6] (0.74) 0.9 [0.4-2.0] (0.79) 
    G/G 4 (3.5) 1 (1.2) 0.4 [0.0-3.3] (0.36) 0.6 [0.1-6.2] (0.71) 2 (2.6) 0 (0.0) 
GenotypeMixed ethnicity
Caucasian
No. patientsNode-negative, n (%)Node-positive, n (%)Crude OR [95% CI] (P)Adjusted* OR [95% CI] (P)No. patientsNode-negative, n (%)Node-positive, n (%)Crude OR [95% CI] (P)Adjusted* OR [95% CI] (P)
MMP-1           
    1G/1G 52 35 (27.8) 17 (18.5) 1.0 1.0 38 26 (29.5) 12 (23) 1.0 1.0 
    1G/2G 101 64 (50.8) 37 (40.2) 1.2 [0.6-2.4] (0.63) 1.2 [0.5-2.6] (0.75) 63 43 (48.9) 20 (38.5) 1.01 [0.3-2.4] (0.98) 0.9 [0.4-2.3] (0.83) 
    2G/2G 65 27 (21.4) 38 (41.3) 2.9 [1.4-6.2] (0.01) 3.9 [1.7-9.4] (0.001) 39 19 (21.6) 20 (38.5) 2.3 [0.9-5.8] (0.08) 2.6 [1.0-6.9] (0.06) 
MMP-3           
    5A/5A 49 26 (20.9) 23 (25.5) 1.0 1.0 39 23 (27) 16 (32) 1.0 1.0 
    5A/6A 114 70 (56.5) 44 (49) 0.7 [0.4-1.4] (0.32) 1.1 [0.5-2.3] (0.88) 73 44 (51.8) 29 (58) 1.0 [0.4-2.1] (0.89) 1.1 [0.5-2.4] (0.92) 
    6A/6A 51 28 (22.6) 23 (25.5) 0.9 [0.4-2.0] (0.85) 0.8 [0.3-2.0] (0.63) 23 18 (21.2) 5 (10) 0.4 [0.1-1.3] (0.40) 0.3 [0.1-1.2] (0.10) 
MMP-7           
    A/A 70 37 (31.4) 33 (37.9) 1.0 1.0 47 30 (37) 17 (34.7) 1.0 1.0 
    A/G 96 60 (50.8) 36 (41.4) 0.7 [0.4-1.3] (0.21) 0.6 [0.3-1.2] (0.17) 59 39 (48) 20 (42.5) 0.9 [0.4-2.0] (0.81) 0.7 [0.3-1.7] (0.54) 
    G/G 39 21 (17.8) 18 (20.7) 1.0 [0.4-2.1] (0.92) 0.7 [0.3-1.7] (0.40) 24 12 (15) 12 (22.8) 1.8 [0.7-4.8] (0.26) 1.3 [0.4-3.7] (0.65) 
MMP-9           
    C/C 167 105 (93.7) 62 (81.6) 1.0 1.0 109 74 (97.3) 35 (81.3) 1.0 1.0 
    C/T 21 7 (6.3) 14 (18.4) 3.4 [1.3-8.9] (0.01) 3.6 [1.2. 11.1] (0.001) 10 2 (2.7) 8 (19.7) 8.5 [1.7-41.9] (0.01) 9.1 [1.7-48.4] (0.01) 
MMP-12           
    A/A 168 98 (80.3) 70 (82.4) 1.0 1.0 107 67 (80.7) 40 (83.3) 1.0 1.0 
    A/G 39 24 (19.7) 15 (17.6) 0.9 [0.4-1.8] (71) 1.2 [0.5-2.8] (0.63) 24 16 (19.3) 8 (16.7) 0.8 [0.3-2.1] (0.71) 1.1 [0.4-2.8] (0.91) 
MMP-13           
    A/A 105 62 (54.9) 43 (53.8) 1.0 1.0 71 44 (56.4) 27 (61.4) 1.0 1.0 
    A/G 83 47 (41.6) 36 (45) 1.1 [0.6-2.0] (0.74) 1.2 [0.6-2.3] (0.62) 49 32 (41) 17 (38.6) 0.8 [0.4-1.6] (0.74) 0.9 [0.4-2.0] (0.79) 
    G/G 4 (3.5) 1 (1.2) 0.4 [0.0-3.3] (0.36) 0.6 [0.1-6.2] (0.71) 2 (2.6) 0 (0.0) 

NOTE: Values in bold indicate significant results.

Abbreviation: OR, odds ratio.

*

Adjusted for tumor grade.

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