Cox multivariate analysis of overall survival
| Variable . | HR (95% CI) . | P* . |
|---|---|---|
| Lymph node status | 4.319 (2.053-9.088) | <0.0005 |
| P-S167 | 0.529 (0.305-0.917) | 0.023 |
| P-AKT (1)† | 2.154 (1.066-4.351) | 0.033 |
| P-AKT (2) | 3.132 (1.419-6.913) | 0.005 |
| Grade 1 vs 2 | 2.310 (0.556-9.599) | 0.249 |
| Grade 1 vs 3 | 6.027 (1.413-25. 702) | 0.015 |
| Variable . | HR (95% CI) . | P* . |
|---|---|---|
| Lymph node status | 4.319 (2.053-9.088) | <0.0005 |
| P-S167 | 0.529 (0.305-0.917) | 0.023 |
| P-AKT (1)† | 2.154 (1.066-4.351) | 0.033 |
| P-AKT (2) | 3.132 (1.419-6.913) | 0.005 |
| Grade 1 vs 2 | 2.310 (0.556-9.599) | 0.249 |
| Grade 1 vs 3 | 6.027 (1.413-25. 702) | 0.015 |
NOTE: Multivariate analysis was done using stepwise Cox proportional hazards regression with forward selection. Candidate exploratory variables included age, tumor size, tumor grade, lymph nodes, ER, PR, HER2, P-MAPK, P-AKT, P-p90RSK, P-S118, and P-S167, where ER and PR were continuous.
Two-sided Wald test was used.
P-AKT (1) is the comparison of cases scored negative for P-AKT compared with cases receiving a score of 1. P-AKT (2) is the comparison of cases scored negative for P-AKT compared with cases receiving a score of 2.