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Table 5.

Cox multivariate analysis of overall survival

VariableHR (95% CI)P*
Lymph node status 4.319 (2.053-9.088) <0.0005 
P-S167 0.529 (0.305-0.917) 0.023 
P-AKT (1) 2.154 (1.066-4.351) 0.033 
P-AKT (2) 3.132 (1.419-6.913) 0.005 
Grade 1 vs 2 2.310 (0.556-9.599) 0.249 
Grade 1 vs 3 6.027 (1.413-25. 702) 0.015 
VariableHR (95% CI)P*
Lymph node status 4.319 (2.053-9.088) <0.0005 
P-S167 0.529 (0.305-0.917) 0.023 
P-AKT (1) 2.154 (1.066-4.351) 0.033 
P-AKT (2) 3.132 (1.419-6.913) 0.005 
Grade 1 vs 2 2.310 (0.556-9.599) 0.249 
Grade 1 vs 3 6.027 (1.413-25. 702) 0.015 

NOTE: Multivariate analysis was done using stepwise Cox proportional hazards regression with forward selection. Candidate exploratory variables included age, tumor size, tumor grade, lymph nodes, ER, PR, HER2, P-MAPK, P-AKT, P-p90RSK, P-S118, and P-S167, where ER and PR were continuous.

*

Two-sided Wald test was used.

P-AKT (1) is the comparison of cases scored negative for P-AKT compared with cases receiving a score of 1. P-AKT (2) is the comparison of cases scored negative for P-AKT compared with cases receiving a score of 2.

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