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Table 2.

Median effects of dasatinib and pyridone 6 as single agents and in combination

Cell lineSingle agent, IC50 (μmol/L)
Combination, IC50 (μmol/L)
CI simulations
DasatinibPyridone 6DasatinibPyridone 6Fa = 0.5Fa = 0.75
Tu167 0.06 ± 0.02 2.6 ± 1.9 0.015 ± 0.007 0.39 ± 0.18 0.39 ± 0.18 0.69 ± 0.38 
Tu686 0.37 ± 0.02* 44 ± 42* 0.005 ± 0.020 0.30 ± 0.11 0.140 ± 0.054 0.208 ± 0.141 
A549 5.4 ± 5.0* 41 ± 31* 0.27 ± 0.11 1.6 ± 0.6 0.089 ± 0.112 0.051 ± 0.104 
H226 1.6 ± 1.2* 2.2 ± 1.5 0.20 ± 0.06 1.2 ± 0.4 0.66 ± 0.35 2.1 ± 1.7* 
Cell lineSingle agent, IC50 (μmol/L)
Combination, IC50 (μmol/L)
CI simulations
DasatinibPyridone 6DasatinibPyridone 6Fa = 0.5Fa = 0.75
Tu167 0.06 ± 0.02 2.6 ± 1.9 0.015 ± 0.007 0.39 ± 0.18 0.39 ± 0.18 0.69 ± 0.38 
Tu686 0.37 ± 0.02* 44 ± 42* 0.005 ± 0.020 0.30 ± 0.11 0.140 ± 0.054 0.208 ± 0.141 
A549 5.4 ± 5.0* 41 ± 31* 0.27 ± 0.11 1.6 ± 0.6 0.089 ± 0.112 0.051 ± 0.104 
H226 1.6 ± 1.2* 2.2 ± 1.5 0.20 ± 0.06 1.2 ± 0.4 0.66 ± 0.35 2.1 ± 1.7* 

NOTE: Data are presented as mean ± SD.

*

Extrapolated.

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