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Table 1.

Human melanoma antigens

• Melanocyte lineage/differentiation antigens: abundant proteins function in melanin production 
    Tyrosinase: human homologue of the mouse albino locus 
    gp 75: tyrosinase related protein-1 (TRP-1); human homologue of the mouse brown locus 
    gp100: Pmel17; target for monoclonal antibody HMB45; the human homologue of the mouse silver locus 
    Melan A/MART-1 
    TRP-2 
• Oncofetal/cancer-testis antigens: normally expressed testis and placenta 
    MAGE family 
    BAGE family 
    GAGE family 
    NY-ESO-1 
• Tumor-specific antigens: subtle mutations of normal cellular proteins, examples of coding region mutations 
    CDK4 
    β-catenin 
• Other mutated peptides: activated as a result of cellular transformation 
    Mutated introns 
    N-acetylglucosaminyltransferase V gene product 
    MUM-1 
    p15 
• Antigens identified by monoclonal antibodies 
    Gangliosides (GM2, GD2, GM3, and GD3) 
    High molecular weight chondroitin sulfate proteoglycan 
    p97 melanotransferrin 
• SEREX antigens 
    D-1 
    SSX-2 
• Melanocyte lineage/differentiation antigens: abundant proteins function in melanin production 
    Tyrosinase: human homologue of the mouse albino locus 
    gp 75: tyrosinase related protein-1 (TRP-1); human homologue of the mouse brown locus 
    gp100: Pmel17; target for monoclonal antibody HMB45; the human homologue of the mouse silver locus 
    Melan A/MART-1 
    TRP-2 
• Oncofetal/cancer-testis antigens: normally expressed testis and placenta 
    MAGE family 
    BAGE family 
    GAGE family 
    NY-ESO-1 
• Tumor-specific antigens: subtle mutations of normal cellular proteins, examples of coding region mutations 
    CDK4 
    β-catenin 
• Other mutated peptides: activated as a result of cellular transformation 
    Mutated introns 
    N-acetylglucosaminyltransferase V gene product 
    MUM-1 
    p15 
• Antigens identified by monoclonal antibodies 
    Gangliosides (GM2, GD2, GM3, and GD3) 
    High molecular weight chondroitin sulfate proteoglycan 
    p97 melanotransferrin 
• SEREX antigens 
    D-1 
    SSX-2 
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