Human melanoma antigens
| • Melanocyte lineage/differentiation antigens: abundant proteins function in melanin production |
| Tyrosinase: human homologue of the mouse albino locus |
| gp 75: tyrosinase related protein-1 (TRP-1); human homologue of the mouse brown locus |
| gp100: Pmel17; target for monoclonal antibody HMB45; the human homologue of the mouse silver locus |
| Melan A/MART-1 |
| TRP-2 |
| • Oncofetal/cancer-testis antigens: normally expressed testis and placenta |
| MAGE family |
| BAGE family |
| GAGE family |
| NY-ESO-1 |
| • Tumor-specific antigens: subtle mutations of normal cellular proteins, examples of coding region mutations |
| CDK4 |
| β-catenin |
| • Other mutated peptides: activated as a result of cellular transformation |
| Mutated introns |
| N-acetylglucosaminyltransferase V gene product |
| MUM-1 |
| p15 |
| • Antigens identified by monoclonal antibodies |
| Gangliosides (GM2, GD2, GM3, and GD3) |
| High molecular weight chondroitin sulfate proteoglycan |
| p97 melanotransferrin |
| • SEREX antigens |
| D-1 |
| SSX-2 |
| • Melanocyte lineage/differentiation antigens: abundant proteins function in melanin production |
| Tyrosinase: human homologue of the mouse albino locus |
| gp 75: tyrosinase related protein-1 (TRP-1); human homologue of the mouse brown locus |
| gp100: Pmel17; target for monoclonal antibody HMB45; the human homologue of the mouse silver locus |
| Melan A/MART-1 |
| TRP-2 |
| • Oncofetal/cancer-testis antigens: normally expressed testis and placenta |
| MAGE family |
| BAGE family |
| GAGE family |
| NY-ESO-1 |
| • Tumor-specific antigens: subtle mutations of normal cellular proteins, examples of coding region mutations |
| CDK4 |
| β-catenin |
| • Other mutated peptides: activated as a result of cellular transformation |
| Mutated introns |
| N-acetylglucosaminyltransferase V gene product |
| MUM-1 |
| p15 |
| • Antigens identified by monoclonal antibodies |
| Gangliosides (GM2, GD2, GM3, and GD3) |
| High molecular weight chondroitin sulfate proteoglycan |
| p97 melanotransferrin |
| • SEREX antigens |
| D-1 |
| SSX-2 |