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Table 5

Grade 3/4 adverse events in fully supplemented versus never supplemented patients treated with pemetrexed plus cisplatin

Adverse eventsFully supplemented, % (n = 168)Never supplemented, % (n = 32)
Neutrophils/granulocytes 24.4 37.5 
Fatigue 17.3 31.3 
Leukocytes 15.5 34.4 
Nausea 11.9 31.3 
Dyspnea 11.3 12.5 
Hypertension 11.3 3.1 
Vomiting 10.7 34.4 
Chest pain 8.3 6.3 
Hemoglobin 6.0 9.4 
Thrombosis/embolism 6.0 3.1 
Platelets 5.4 9.4 
Tumor pain 4.8 6.3 
Dehydration 4.2 9.4 
Constipation 3.6 3.1 
Diarrhea without colostomy 3.6 9.4 
Febrile neutropenia 0.6 9.4 
Infection with grade3/4 neutropenia 0.6 6.3 
Adverse eventsFully supplemented, % (n = 168)Never supplemented, % (n = 32)
Neutrophils/granulocytes 24.4 37.5 
Fatigue 17.3 31.3 
Leukocytes 15.5 34.4 
Nausea 11.9 31.3 
Dyspnea 11.3 12.5 
Hypertension 11.3 3.1 
Vomiting 10.7 34.4 
Chest pain 8.3 6.3 
Hemoglobin 6.0 9.4 
Thrombosis/embolism 6.0 3.1 
Platelets 5.4 9.4 
Tumor pain 4.8 6.3 
Dehydration 4.2 9.4 
Constipation 3.6 3.1 
Diarrhea without colostomy 3.6 9.4 
Febrile neutropenia 0.6 9.4 
Infection with grade3/4 neutropenia 0.6 6.3 
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