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Table 2

Univariate analysis for OS and PFS for all patients in the cohort

OS
PFS
Prognostic factors at transplantationRR (95% confidence interval)PRR (95% confidence interval)P
ALC-15 ≥ 0.5 × 109 lymphocyte/kg 0.459 (0.267-0.710) 0.0002 0.527 (0.355-0.741) 0.0001 
β-2 Microglobulin ≥ 2.7 mg/L 1.482 (1.039-2.085) 0.031 1.475 (1.093-1.967) 0.012 
Circulating plasma cells >1% 2.601 (1.255-4.501) 0.014 2.491 (1.351-4.000) 0.006 
Conditioning regimen: melphalan/total body irradiation versus melphalan alone 0.638 (0.407-1.106) 0.102 0.716 (0.494-1.119) 0.132 
C-reactive protein ≥ 0.8 mg/L 1.375 (0.870-2.030) 0.160   
Creatinine > 2.0 mg/L   1.475 (0.910-2.177) 0.107 
Interventricular septal thickness ≥ 15 mm 1.523 (1.069-2.141) 0.021 1.424 (1.045-1.908) 0.026 
LDH > normal 1.477 (0.933-2.183) 0.091 1.526 (1.045-2.127) 0.030 
No. organs involved > 2 1.876 (1.289-2.671) 0.0015 1.796 (1.300-2.429) 0.0007 
No. prior therapies to ASCT ≥ 1   1.316 (0.984-1.743) 0.06 
Stem cell mobilization regimen:     
G-CSF versus Cytoxan/GM-CSF 0.666 (0.456-1.002) 0.051 0.766 (0.570-1.054) 0.100 
Troponin T ≥ 0.035* 2.278 (1.413-3.593) 0.0012 2.177 (1.492-3.111) 0.0001 
Urine M protein > 0.25 g/d 1.319 (0.907-1.919) 0.146 1.412 (1.066-1.876) 0.016 
OS
PFS
Prognostic factors at transplantationRR (95% confidence interval)PRR (95% confidence interval)P
ALC-15 ≥ 0.5 × 109 lymphocyte/kg 0.459 (0.267-0.710) 0.0002 0.527 (0.355-0.741) 0.0001 
β-2 Microglobulin ≥ 2.7 mg/L 1.482 (1.039-2.085) 0.031 1.475 (1.093-1.967) 0.012 
Circulating plasma cells >1% 2.601 (1.255-4.501) 0.014 2.491 (1.351-4.000) 0.006 
Conditioning regimen: melphalan/total body irradiation versus melphalan alone 0.638 (0.407-1.106) 0.102 0.716 (0.494-1.119) 0.132 
C-reactive protein ≥ 0.8 mg/L 1.375 (0.870-2.030) 0.160   
Creatinine > 2.0 mg/L   1.475 (0.910-2.177) 0.107 
Interventricular septal thickness ≥ 15 mm 1.523 (1.069-2.141) 0.021 1.424 (1.045-1.908) 0.026 
LDH > normal 1.477 (0.933-2.183) 0.091 1.526 (1.045-2.127) 0.030 
No. organs involved > 2 1.876 (1.289-2.671) 0.0015 1.796 (1.300-2.429) 0.0007 
No. prior therapies to ASCT ≥ 1   1.316 (0.984-1.743) 0.06 
Stem cell mobilization regimen:     
G-CSF versus Cytoxan/GM-CSF 0.666 (0.456-1.002) 0.051 0.766 (0.570-1.054) 0.100 
Troponin T ≥ 0.035* 2.278 (1.413-3.593) 0.0012 2.177 (1.492-3.111) 0.0001 
Urine M protein > 0.25 g/d 1.319 (0.907-1.919) 0.146 1.412 (1.066-1.876) 0.016 
*

Only available data in 102 patients.

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