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Table 2

MMP gene expression

(A) Gene expression data from all investigated MMPs
Gene nameExpression (lung)Expression (tumor)t test (P)Fold-change (tumor/lung)
Matrix metalloproteinase 1 60.0 220.0 1.9 × 10−11 3.7 
Matrix metalloproteinase 2 789.0 807.0 0.7 1.0 
Matrix metalloproteinase 3 60.0 64.5 0.04 1.0 
Matrix metalloproteinase 7 228.0 386.5 0.004 1.7 
Matrix metalloproteinase 8 81.0 99.0 0.004 1.2 
Matrix metalloproteinase 9 252.0 530.0 5.5 × 10−10 2.1 
Matrix metalloproteinase 10 60.0 185.6 3.1 × 10−6 3.0 
Matrix metalloproteinase 11 213.9 342.8 7.9 × 10−8 1.6 
Matrix metalloproteinase 12 60.0 248.7 1.4 × 10−20 4.1 
Matrix metalloproteinase 13 60.0 85.0 0.002 1.4 
Matrix metalloproteinase 14 319.0 413.2 0.001 1.3 
Matrix metalloproteinase 15 65.8 71.6 0.08 1.0 
Matrix metalloproteinase 16 60.0 60.0 1.0 1.0 
Matrix metalloproteinase 17 139.8 163.9 0.01 1.1 
Matrix metalloproteinase 19 93.9 61.7 0.02 0.6 
Matrix metalloproteinase 20 60.0 60.0 1.0 1.0 
Matrix metalloproteinase 23B 402.5 308.0 0.007 0.7 
Matrix metalloproteinase 24 306.0 314.0 0.4 1.0 
Matrix metalloproteinase 25 213.5 163.5 0.02 0.7 
Matrix metalloproteinase 26 60.0 60.0 1.0 1.0 
Matrix metalloproteinase 27 60.0 60.0 1.0 1.0 
Matrix metalloproteinase 28
 
209.5
 
212.5
 
0.73
 
1.0
 
(B) Differently expressed MMPs in correlation to tumor relapse (local recurrence and/or distant metastasis)
 
       
Gene
 
Expression
 
n
 
No recurrence
 
Local recurrence
 
Distant metastasis
 
Both
 
P
 
MMP-1 Low expression 34 21 (61.8%) 3 (8.8%) 7 (20.6%) 3 (8.8%) 0.53 
 High expression 36 18 (50.0%) 2 (5.6%) 13 (36.1%) 3 (8.3%)  
MMP-9 Low expression 18 12 (66.7%) 1 (5.6%) 3 (16.7%) 2 (11.1%) 0.57 
 High expression 52 27 (51.9%) 4 (7.7%) 17 (32.4%) 4 (7.7%)  
MMP-10 Low expression 47 24 (51.1%) 3 (6.4%) 16 (34.0%) 4 (8.5%)  
 High expression 23 15 (65.2%) 2 (8.7%) 4 (17.4%) 2 (8.7%) 0.53 
MMP-11 Low expression 38 21 (55.3%) 3 (7.9%) 10 (26.3%) 4 (10.5%) 0.89 
 High expression 32 18 (56.3%) 2 (6.3%) 10 (31.3%) 2 (6.3%)  
MMP-12 Low expression 14 12 (85.7%) 1 (7.1%) 0% 1 (7.1%) 0.04 
 High expression 56 27 (48.2%) 4 (7.1%) 20 (35.7%) 5 (8.9%)  
(A) Gene expression data from all investigated MMPs
Gene nameExpression (lung)Expression (tumor)t test (P)Fold-change (tumor/lung)
Matrix metalloproteinase 1 60.0 220.0 1.9 × 10−11 3.7 
Matrix metalloproteinase 2 789.0 807.0 0.7 1.0 
Matrix metalloproteinase 3 60.0 64.5 0.04 1.0 
Matrix metalloproteinase 7 228.0 386.5 0.004 1.7 
Matrix metalloproteinase 8 81.0 99.0 0.004 1.2 
Matrix metalloproteinase 9 252.0 530.0 5.5 × 10−10 2.1 
Matrix metalloproteinase 10 60.0 185.6 3.1 × 10−6 3.0 
Matrix metalloproteinase 11 213.9 342.8 7.9 × 10−8 1.6 
Matrix metalloproteinase 12 60.0 248.7 1.4 × 10−20 4.1 
Matrix metalloproteinase 13 60.0 85.0 0.002 1.4 
Matrix metalloproteinase 14 319.0 413.2 0.001 1.3 
Matrix metalloproteinase 15 65.8 71.6 0.08 1.0 
Matrix metalloproteinase 16 60.0 60.0 1.0 1.0 
Matrix metalloproteinase 17 139.8 163.9 0.01 1.1 
Matrix metalloproteinase 19 93.9 61.7 0.02 0.6 
Matrix metalloproteinase 20 60.0 60.0 1.0 1.0 
Matrix metalloproteinase 23B 402.5 308.0 0.007 0.7 
Matrix metalloproteinase 24 306.0 314.0 0.4 1.0 
Matrix metalloproteinase 25 213.5 163.5 0.02 0.7 
Matrix metalloproteinase 26 60.0 60.0 1.0 1.0 
Matrix metalloproteinase 27 60.0 60.0 1.0 1.0 
Matrix metalloproteinase 28
 
209.5
 
212.5
 
0.73
 
1.0
 
(B) Differently expressed MMPs in correlation to tumor relapse (local recurrence and/or distant metastasis)
 
       
Gene
 
Expression
 
n
 
No recurrence
 
Local recurrence
 
Distant metastasis
 
Both
 
P
 
MMP-1 Low expression 34 21 (61.8%) 3 (8.8%) 7 (20.6%) 3 (8.8%) 0.53 
 High expression 36 18 (50.0%) 2 (5.6%) 13 (36.1%) 3 (8.3%)  
MMP-9 Low expression 18 12 (66.7%) 1 (5.6%) 3 (16.7%) 2 (11.1%) 0.57 
 High expression 52 27 (51.9%) 4 (7.7%) 17 (32.4%) 4 (7.7%)  
MMP-10 Low expression 47 24 (51.1%) 3 (6.4%) 16 (34.0%) 4 (8.5%)  
 High expression 23 15 (65.2%) 2 (8.7%) 4 (17.4%) 2 (8.7%) 0.53 
MMP-11 Low expression 38 21 (55.3%) 3 (7.9%) 10 (26.3%) 4 (10.5%) 0.89 
 High expression 32 18 (56.3%) 2 (6.3%) 10 (31.3%) 2 (6.3%)  
MMP-12 Low expression 14 12 (85.7%) 1 (7.1%) 0% 1 (7.1%) 0.04 
 High expression 56 27 (48.2%) 4 (7.1%) 20 (35.7%) 5 (8.9%)  
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