American Association for Cancer Research

Table 4.

Maximum plasma total catechin concentrations (ng/mL) after oral administration of Polyphenon E in the absence or presence of food

Catechin	Polyphenon E (400 mg epigallocatechin gallate)			Polyphenon E (800 mg epigallocatechin gallate)
	Fed	Fasting	Fed	Fasting	Fed	Fasting
Epigallocatechin	128.6 ± 74.9*	81.8 ± 67.3	177.1 ± 86.2	135.5 ± 83.6	200.3 ± 115.1	323.4 ± 231.1
Epicatechin	156.3 ± 98.1	94.7 ± 63.3^†	234.0 ± 122.7	149.8 ± 79.7^†	346.2 ± 218.0	272.3 ± 173.6^†
Epigallocatechin gallate	174.4 ± 80.6	754.9 ± 399.9^‡	360.1 ± 136.9	1,622.7 ± 1,501.4^‡	871.9 ± 625.3	3,988.4 ± 2,068.2^‡
Epicatechin gallate	21.2 ± 9.0	86.3 ± 48.8^‡	48.7 ± 17.5	197.5 ± 179.3^‡	117.5 ± 91.5	450.7 ± 218.7^‡

Catechin	Polyphenon E (400 mg epigallocatechin gallate)			Polyphenon E (800 mg epigallocatechin gallate)
	Fed	Fasting	Fed	Fasting	Fed	Fasting
Epigallocatechin	128.6 ± 74.9*	81.8 ± 67.3	177.1 ± 86.2	135.5 ± 83.6	200.3 ± 115.1	323.4 ± 231.1
Epicatechin	156.3 ± 98.1	94.7 ± 63.3^†	234.0 ± 122.7	149.8 ± 79.7^†	346.2 ± 218.0	272.3 ± 173.6^†
Epigallocatechin gallate	174.4 ± 80.6	754.9 ± 399.9^‡	360.1 ± 136.9	1,622.7 ± 1,501.4^‡	871.9 ± 625.3	3,988.4 ± 2,068.2^‡
Epicatechin gallate	21.2 ± 9.0	86.3 ± 48.8^‡	48.7 ± 17.5	197.5 ± 179.3^‡	117.5 ± 91.5	450.7 ± 218.7^‡

Mean ± one SD.

Significantly different from the fed condition, P < 0.005 when data were pooled from all doses.

Significantly different from the fed condition, P < 0.0001 when data were pooled from all doses.