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Table 4.

Maximum plasma total catechin concentrations (ng/mL) after oral administration of Polyphenon E in the absence or presence of food

CatechinPolyphenon E (400 mg epigallocatechin gallate)
Polyphenon E (800 mg epigallocatechin gallate)
Polyphenon E (1,200 mg epigallocatechin gallate)
FedFastingFedFastingFedFasting
Epigallocatechin 128.6 ± 74.9* 81.8 ± 67.3 177.1 ± 86.2 135.5 ± 83.6 200.3 ± 115.1 323.4 ± 231.1 
Epicatechin 156.3 ± 98.1 94.7 ± 63.3 234.0 ± 122.7 149.8 ± 79.7 346.2 ± 218.0 272.3 ± 173.6 
Epigallocatechin gallate 174.4 ± 80.6 754.9 ± 399.9 360.1 ± 136.9 1,622.7 ± 1,501.4 871.9 ± 625.3 3,988.4 ± 2,068.2 
Epicatechin gallate 21.2 ± 9.0 86.3 ± 48.8 48.7 ± 17.5 197.5 ± 179.3 117.5 ± 91.5 450.7 ± 218.7 
CatechinPolyphenon E (400 mg epigallocatechin gallate)
Polyphenon E (800 mg epigallocatechin gallate)
Polyphenon E (1,200 mg epigallocatechin gallate)
FedFastingFedFastingFedFasting
Epigallocatechin 128.6 ± 74.9* 81.8 ± 67.3 177.1 ± 86.2 135.5 ± 83.6 200.3 ± 115.1 323.4 ± 231.1 
Epicatechin 156.3 ± 98.1 94.7 ± 63.3 234.0 ± 122.7 149.8 ± 79.7 346.2 ± 218.0 272.3 ± 173.6 
Epigallocatechin gallate 174.4 ± 80.6 754.9 ± 399.9 360.1 ± 136.9 1,622.7 ± 1,501.4 871.9 ± 625.3 3,988.4 ± 2,068.2 
Epicatechin gallate 21.2 ± 9.0 86.3 ± 48.8 48.7 ± 17.5 197.5 ± 179.3 117.5 ± 91.5 450.7 ± 218.7 
*

Mean ± one SD.

Significantly different from the fed condition, P < 0.005 when data were pooled from all doses.

Significantly different from the fed condition, P < 0.0001 when data were pooled from all doses.

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