American Association for Cancer Research

Table 3.

Maximum plasma free catechin concentrations (ng/mL) after oral administration of Polyphenon E in the absence or presence of food

Catechin	Polyphenon E (400 mg epigallocatechin gallate)			Polyphenon E (800 mg epigallocatechin gallate)
	Fed	Fasting	Fed	Fasting	Fed	Fasting
Epigallocatechin	15.9 ± 16.4*	39.7 ± 44.6^†	34.1 ± 20.3	74.3 ± 70.0^†	42.9 ± 36.7	131.0 ± 94.2^†
Epicatechin	1.6 ± 3.9	5.6 ± 7.8	2.8 ± 5.0	1.9 ± 3.4	10.1 ± 15.3	16.6 ± 30.0
Epigallocatechin gallate	141.8 ± 89.1	798.7 ± 573.1^‡	294.0 ± 113.5	1,522.4 ± 1,357.8^‡	923.6 ± 755.3	3,371.6 ± 1,651.2^‡
Epicatechin gallate	15.7 ± 8.8	87.6 ± 62.0^‡	33.9 ± 11.0	174.4 ± 141.1^‡	112.9 ± 88.2	382.6 ± 176.0^‡

Catechin	Polyphenon E (400 mg epigallocatechin gallate)			Polyphenon E (800 mg epigallocatechin gallate)
	Fed	Fasting	Fed	Fasting	Fed	Fasting
Epigallocatechin	15.9 ± 16.4*	39.7 ± 44.6^†	34.1 ± 20.3	74.3 ± 70.0^†	42.9 ± 36.7	131.0 ± 94.2^†
Epicatechin	1.6 ± 3.9	5.6 ± 7.8	2.8 ± 5.0	1.9 ± 3.4	10.1 ± 15.3	16.6 ± 30.0
Epigallocatechin gallate	141.8 ± 89.1	798.7 ± 573.1^‡	294.0 ± 113.5	1,522.4 ± 1,357.8^‡	923.6 ± 755.3	3,371.6 ± 1,651.2^‡
Epicatechin gallate	15.7 ± 8.8	87.6 ± 62.0^‡	33.9 ± 11.0	174.4 ± 141.1^‡	112.9 ± 88.2	382.6 ± 176.0^‡

Mean ± one SD.

Significantly different from the fed condition, P < 0.001 when data were pooled from all doses.

Significantly different from the fed condition, P < 0.0001 when data were pooled from all doses.