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Table 3.

Maximum plasma free catechin concentrations (ng/mL) after oral administration of Polyphenon E in the absence or presence of food

CatechinPolyphenon E (400 mg epigallocatechin gallate)
Polyphenon E (800 mg epigallocatechin gallate)
Polyphenon E (1,200 mg epigallocatechin gallate)
FedFastingFedFastingFedFasting
Epigallocatechin 15.9 ± 16.4* 39.7 ± 44.6 34.1 ± 20.3 74.3 ± 70.0 42.9 ± 36.7 131.0 ± 94.2 
Epicatechin 1.6 ± 3.9 5.6 ± 7.8 2.8 ± 5.0 1.9 ± 3.4 10.1 ± 15.3 16.6 ± 30.0 
Epigallocatechin gallate 141.8 ± 89.1 798.7 ± 573.1 294.0 ± 113.5 1,522.4 ± 1,357.8 923.6 ± 755.3 3,371.6 ± 1,651.2 
Epicatechin gallate 15.7 ± 8.8 87.6 ± 62.0 33.9 ± 11.0 174.4 ± 141.1 112.9 ± 88.2 382.6 ± 176.0 
CatechinPolyphenon E (400 mg epigallocatechin gallate)
Polyphenon E (800 mg epigallocatechin gallate)
Polyphenon E (1,200 mg epigallocatechin gallate)
FedFastingFedFastingFedFasting
Epigallocatechin 15.9 ± 16.4* 39.7 ± 44.6 34.1 ± 20.3 74.3 ± 70.0 42.9 ± 36.7 131.0 ± 94.2 
Epicatechin 1.6 ± 3.9 5.6 ± 7.8 2.8 ± 5.0 1.9 ± 3.4 10.1 ± 15.3 16.6 ± 30.0 
Epigallocatechin gallate 141.8 ± 89.1 798.7 ± 573.1 294.0 ± 113.5 1,522.4 ± 1,357.8 923.6 ± 755.3 3,371.6 ± 1,651.2 
Epicatechin gallate 15.7 ± 8.8 87.6 ± 62.0 33.9 ± 11.0 174.4 ± 141.1 112.9 ± 88.2 382.6 ± 176.0 
*

Mean ± one SD.

Significantly different from the fed condition, P < 0.001 when data were pooled from all doses.

Significantly different from the fed condition, P < 0.0001 when data were pooled from all doses.

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