American Association for Cancer Research

Table 2.

Pharmacokinetic variables of free epigallocatechin gallate after oral administration of Polyphenon E in the absence or presence of food

Pharmacokinetic variables	Polyphenon E (400 mg epigallocatechin gallate)			Polyphenon E (800 mg epigallocatechin gallate)
	Fed	Fasting	Fed	Fasting	Fed	Fasting
AUC (min · μg/mL)	36.70 ± 24.66*	126.96 ± 47.02^†	90.89 ± 37.39	254.48 ± 214.21^†	299.40 ± 285.86	685.53 ± 394.33^†
C_max (ng/mL)	141.8 ± 89.1	798.7 ± 573.1^†	294.0 ± 113.5	1,522.4 ± 1,357.8^†	923.6 ± 755.3	3,371.6 ± 1,651.2^†
T_max (min)	122.90 ± 83.70	93.90 ± 58.99^‡	154.90 ± 78.31	83.30 ± 31.04^‡	175.10 ± 74.58	90.60 ± 28.37^‡
CL/F (L/min)	14.53 ± 7.84	3.64 ± 1.55^†	11.63 ± 9.25	4.80 ± 2.69^†	7.39 ± 4.86	2.37 ± 1.32^†
Vd/F (L)	2,872.8 ± 2,672.8	912.4 ± 695.6^†	3,112.9 ± 2,810.8	946.6 ± 558.3^†	2,825.1 ± 2,257.7	664.0 ± 223.5^†
t_1/2 (min)	145.2 ± 129.1	170.5 ± 104.6	220.9 ± 209.3	156.5 ± 77.5	254.9 ± 59.9^§	228.4 ± 75.3

Pharmacokinetic variables	Polyphenon E (400 mg epigallocatechin gallate)			Polyphenon E (800 mg epigallocatechin gallate)
	Fed	Fasting	Fed	Fasting	Fed	Fasting
AUC (min · μg/mL)	36.70 ± 24.66*	126.96 ± 47.02^†	90.89 ± 37.39	254.48 ± 214.21^†	299.40 ± 285.86	685.53 ± 394.33^†
C_max (ng/mL)	141.8 ± 89.1	798.7 ± 573.1^†	294.0 ± 113.5	1,522.4 ± 1,357.8^†	923.6 ± 755.3	3,371.6 ± 1,651.2^†
T_max (min)	122.90 ± 83.70	93.90 ± 58.99^‡	154.90 ± 78.31	83.30 ± 31.04^‡	175.10 ± 74.58	90.60 ± 28.37^‡
CL/F (L/min)	14.53 ± 7.84	3.64 ± 1.55^†	11.63 ± 9.25	4.80 ± 2.69^†	7.39 ± 4.86	2.37 ± 1.32^†
Vd/F (L)	2,872.8 ± 2,672.8	912.4 ± 695.6^†	3,112.9 ± 2,810.8	946.6 ± 558.3^†	2,825.1 ± 2,257.7	664.0 ± 223.5^†
t_1/2 (min)	145.2 ± 129.1	170.5 ± 104.6	220.9 ± 209.3	156.5 ± 77.5	254.9 ± 59.9^§	228.4 ± 75.3

Mean ± one SD.

Significantly different from the fed condition, P < 0.0001 when data were pooled from all doses.

Significantly different from the fed condition, P < 0.0005 when data were pooled from all doses.

Significantly different from 400 mg dose of the same dosing condition, P < 0.005.