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Table 2.

Pharmacokinetic variables of free epigallocatechin gallate after oral administration of Polyphenon E in the absence or presence of food

Pharmacokinetic variablesPolyphenon E (400 mg epigallocatechin gallate)
Polyphenon E (800 mg epigallocatechin gallate)
Polyphenon E (1,200 mg epigallocatechin gallate)
FedFastingFedFastingFedFasting
AUC (min · μg/mL) 36.70 ± 24.66* 126.96 ± 47.02 90.89 ± 37.39 254.48 ± 214.21 299.40 ± 285.86 685.53 ± 394.33 
Cmax (ng/mL) 141.8 ± 89.1 798.7 ± 573.1 294.0 ± 113.5 1,522.4 ± 1,357.8 923.6 ± 755.3 3,371.6 ± 1,651.2 
Tmax (min) 122.90 ± 83.70 93.90 ± 58.99 154.90 ± 78.31 83.30 ± 31.04 175.10 ± 74.58 90.60 ± 28.37 
CL/F (L/min) 14.53 ± 7.84 3.64 ± 1.55 11.63 ± 9.25 4.80 ± 2.69 7.39 ± 4.86 2.37 ± 1.32 
Vd/F (L) 2,872.8 ± 2,672.8 912.4 ± 695.6 3,112.9 ± 2,810.8 946.6 ± 558.3 2,825.1 ± 2,257.7 664.0 ± 223.5 
t1/2 (min) 145.2 ± 129.1 170.5 ± 104.6 220.9 ± 209.3 156.5 ± 77.5 254.9 ± 59.9§ 228.4 ± 75.3 
Pharmacokinetic variablesPolyphenon E (400 mg epigallocatechin gallate)
Polyphenon E (800 mg epigallocatechin gallate)
Polyphenon E (1,200 mg epigallocatechin gallate)
FedFastingFedFastingFedFasting
AUC (min · μg/mL) 36.70 ± 24.66* 126.96 ± 47.02 90.89 ± 37.39 254.48 ± 214.21 299.40 ± 285.86 685.53 ± 394.33 
Cmax (ng/mL) 141.8 ± 89.1 798.7 ± 573.1 294.0 ± 113.5 1,522.4 ± 1,357.8 923.6 ± 755.3 3,371.6 ± 1,651.2 
Tmax (min) 122.90 ± 83.70 93.90 ± 58.99 154.90 ± 78.31 83.30 ± 31.04 175.10 ± 74.58 90.60 ± 28.37 
CL/F (L/min) 14.53 ± 7.84 3.64 ± 1.55 11.63 ± 9.25 4.80 ± 2.69 7.39 ± 4.86 2.37 ± 1.32 
Vd/F (L) 2,872.8 ± 2,672.8 912.4 ± 695.6 3,112.9 ± 2,810.8 946.6 ± 558.3 2,825.1 ± 2,257.7 664.0 ± 223.5 
t1/2 (min) 145.2 ± 129.1 170.5 ± 104.6 220.9 ± 209.3 156.5 ± 77.5 254.9 ± 59.9§ 228.4 ± 75.3 
*

Mean ± one SD.

Significantly different from the fed condition, P < 0.0001 when data were pooled from all doses.

Significantly different from the fed condition, P < 0.0005 when data were pooled from all doses.

§

Significantly different from 400 mg dose of the same dosing condition, P < 0.005.

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