Toxicity effects of treatment
| Placebo (N = 53) . | . | . | . | . | Pulmicort (N = 53) . | . | . | . | . | ||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Symptom . | Grade 1 . | Grade 2 . | Grade 3 . | Total . | Grade 1 . | Grade 2 . | Grade 3 . | Total . | P * . | ||||||||
| Dry throat | 12† | 0 | 1 | 13 | 11 | 1 | 0 | 12 | 0.82 | ||||||||
| Thirst sensation | 4 | 1 | 0 | 5 | 10 | 1 | 0 | 11 | 0.17 | ||||||||
| Sore mouth | 1 | 2 | 0 | 3 | 2 | 0 | 0 | 2 | 1.0 | ||||||||
| Bad taste | 10 | 1 | 0 | 11 | 15 | 2 | 0 | 17 | 0.27 | ||||||||
| Voice change | 5 | 0 | 0 | 5 | 7 | 5 | 1 | 13 | 0.07 | ||||||||
| Throat irritation | 15 | 4 | 0 | 19 | 19 | 6 | 0 | 25 | 0.32 | ||||||||
| Hoarse voice | 6 | 4 | 0 | 10 | 18 | 9 | 2 | 29 | 0.001 | ||||||||
| Loss of voice | 0 | 1 | 0 | 1 | 0 | 2 | 0 | 2 | 0.56 | ||||||||
| Thrush | 0 | 1 | 0 | 1 | 1 | 2 | 2 | 5 | 0.21 | ||||||||
| Cough | 5 | 2 | 0 | 7 | 17 | 3 | 0 | 20 | 0.008 | ||||||||
| Headache | 11 | 4 | 0 | 15 | 12 | 3 | 0 | 15 | 1.0 | ||||||||
| Fatigue | 10 | 3 | 1 | 14 | 14 | 4 | 0 | 18 | 0.53 | ||||||||
| Nausea | 11 | 2 | 0 | 13 | 3 | 2 | 0 | 5 | 0.07 | ||||||||
| Blurry/itch/dry eyes | 10 | 1 | 0 | 11 | 3 | 0 | 0 | 3 | 0.045 | ||||||||
| Skin bruising | 7 | 0 | 0 | 7 | 8 | 0 | 0 | 8 | 0.78 | ||||||||
| Cortisol suppression | 0 | 0 | 0 | 0 | 5 | 0 | 0 | 5 | 0.07 | ||||||||
| Elevated fasting blood sugar | 3 | 0 | 0 | 3 | 1 | 0 | 0 | 1 | 0.61 | ||||||||
| Placebo (N = 53) . | . | . | . | . | Pulmicort (N = 53) . | . | . | . | . | ||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Symptom . | Grade 1 . | Grade 2 . | Grade 3 . | Total . | Grade 1 . | Grade 2 . | Grade 3 . | Total . | P * . | ||||||||
| Dry throat | 12† | 0 | 1 | 13 | 11 | 1 | 0 | 12 | 0.82 | ||||||||
| Thirst sensation | 4 | 1 | 0 | 5 | 10 | 1 | 0 | 11 | 0.17 | ||||||||
| Sore mouth | 1 | 2 | 0 | 3 | 2 | 0 | 0 | 2 | 1.0 | ||||||||
| Bad taste | 10 | 1 | 0 | 11 | 15 | 2 | 0 | 17 | 0.27 | ||||||||
| Voice change | 5 | 0 | 0 | 5 | 7 | 5 | 1 | 13 | 0.07 | ||||||||
| Throat irritation | 15 | 4 | 0 | 19 | 19 | 6 | 0 | 25 | 0.32 | ||||||||
| Hoarse voice | 6 | 4 | 0 | 10 | 18 | 9 | 2 | 29 | 0.001 | ||||||||
| Loss of voice | 0 | 1 | 0 | 1 | 0 | 2 | 0 | 2 | 0.56 | ||||||||
| Thrush | 0 | 1 | 0 | 1 | 1 | 2 | 2 | 5 | 0.21 | ||||||||
| Cough | 5 | 2 | 0 | 7 | 17 | 3 | 0 | 20 | 0.008 | ||||||||
| Headache | 11 | 4 | 0 | 15 | 12 | 3 | 0 | 15 | 1.0 | ||||||||
| Fatigue | 10 | 3 | 1 | 14 | 14 | 4 | 0 | 18 | 0.53 | ||||||||
| Nausea | 11 | 2 | 0 | 13 | 3 | 2 | 0 | 5 | 0.07 | ||||||||
| Blurry/itch/dry eyes | 10 | 1 | 0 | 11 | 3 | 0 | 0 | 3 | 0.045 | ||||||||
| Skin bruising | 7 | 0 | 0 | 7 | 8 | 0 | 0 | 8 | 0.78 | ||||||||
| Cortisol suppression | 0 | 0 | 0 | 0 | 5 | 0 | 0 | 5 | 0.07 | ||||||||
| Elevated fasting blood sugar | 3 | 0 | 0 | 3 | 1 | 0 | 0 | 1 | 0.61 | ||||||||