MIB-1, p53, and Bcl-2 expression* (mean ± SD) in bronchial biopsies at baseline and after intervention for 6 months
| . | No. of biopsies . | Baseline (%) . | 6 months (%) . |
|---|---|---|---|
| MIB-1 | |||
| Pulmicort | 142 | 28 ± 15 | 21 ± 17 |
| Placebo | 187 | 28 ± 14 | 21 ± 15 |
| p53 | |||
| Pulmicort | 131 | 42 ± 26 | 35 ± 26† |
| Placebo | 163 | 37 ± 27 | 40 ± 27 |
| BCL2 | |||
| Pulmicort | 109 | 19 ± 15 | 16 ± 13‡ |
| Placebo | 139 | 20 ± 13 | 24 ± 15 |
| . | No. of biopsies . | Baseline (%) . | 6 months (%) . |
|---|---|---|---|
| MIB-1 | |||
| Pulmicort | 142 | 28 ± 15 | 21 ± 17 |
| Placebo | 187 | 28 ± 14 | 21 ± 15 |
| p53 | |||
| Pulmicort | 131 | 42 ± 26 | 35 ± 26† |
| Placebo | 163 | 37 ± 27 | 40 ± 27 |
| BCL2 | |||
| Pulmicort | 109 | 19 ± 15 | 16 ± 13‡ |
| Placebo | 139 | 20 ± 13 | 24 ± 15 |
Percentage of positively stained cells per 200 cells.
Percentage of positively stained cells decreased after Pulmicort and increased after placebo. The difference in the change between the two groups was significant (P = 0.01, t test).
Percentage of positively stained cells decreased after Pulmicort (P = 0.042, paired t test) and increased after placebo (P = 0.011, paired t test). The difference in the change between the two arms was statistically significant (P = 0.001).