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Table 4

MIB-1, p53, and Bcl-2 expression* (mean ± SD) in bronchial biopsies at baseline and after intervention for 6 months

No. of biopsiesBaseline (%)6 months (%)
MIB-1    
 Pulmicort 142 28 ± 15 21 ± 17 
 Placebo 187 28 ± 14 21 ± 15 
p53    
 Pulmicort 131 42 ± 26 35 ± 26 
 Placebo 163 37 ± 27 40 ± 27 
BCL2    
 Pulmicort 109 19 ± 15 16 ± 13 
 Placebo 139 20 ± 13 24 ± 15 
No. of biopsiesBaseline (%)6 months (%)
MIB-1    
 Pulmicort 142 28 ± 15 21 ± 17 
 Placebo 187 28 ± 14 21 ± 15 
p53    
 Pulmicort 131 42 ± 26 35 ± 26 
 Placebo 163 37 ± 27 40 ± 27 
BCL2    
 Pulmicort 109 19 ± 15 16 ± 13 
 Placebo 139 20 ± 13 24 ± 15 
*

Percentage of positively stained cells per 200 cells.

Percentage of positively stained cells decreased after Pulmicort and increased after placebo. The difference in the change between the two groups was significant (P = 0.01, t test).

Percentage of positively stained cells decreased after Pulmicort (P = 0.042, paired t test) and increased after placebo (P = 0.011, paired t test). The difference in the change between the two arms was statistically significant (P = 0.001).

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