American Association for Cancer Research

Table 1

Effect of 10% FS and TAM on the body weight, food intake, and relative uterine weight ^*

	Total food intake (6 weeks; g/mouse)	Body weight (g)
Experiment 1 (no E2 pellet implant)		Week 7	Week 13	Week 14
+E2 ^†	74.1 ± 2.4^a	18.0 ± 0.3^a	17.7 ± 0.3^a	5.59 ± 1.21^a
−E2	99.7 ± 3.9^b	18.4 ± 0.3^a	19.3 ± 0.4^a,b	1.13 ± 0.10^b
FS−E2	104.2 ± 4.4^b	17.6 ± 0.5^a	19.9 ± 0.2^b	1.18 ± 0.10^b
TAM−E2	94.5 ± 2.9^b	17.3 ± 0.4^a	18.7 ± 0.4^a,b	1.57 ± 0.12^c
FS+TAM−E2	109.0 ± 4.8^b	17.7 ± 0.3^a	19.2 ± 0.4^a,b	1.46 ± 0.15^b,c
Experiment 2 (with E2 pellet implant)		Week 6	Week 12	Week 12
+E2	97.9 ± 1.0^a	18.3 ± 0.3^a	19.2 ± 0.6^a	2.80 ± 0.65^a
−E2	107.3 ± 3.4^a	17.9 ± 0.3^a	20.5 ± 0.5^a	0.95 ± 0.10^b
FS+E2	95.4 ± 3.5^a	18.5 ± 0.2^a	19.2 ± 0.4^a	2.95 ± 0.17^a
TAM+E2	96.6 ± 9.8^a	18.3 ± 0.3^a	19.0 ± 0.6^a	3.25 ± 0.48^a
FS+TAM+E2	92.0 ± 1.8^a	18.4 ± 0.4^a	18.4 ± 0.5^a	3.26 ± 0.72^a

	Total food intake (6 weeks; g/mouse)	Body weight (g)
Experiment 1 (no E2 pellet implant)		Week 7	Week 13	Week 14
+E2 ^†	74.1 ± 2.4^a	18.0 ± 0.3^a	17.7 ± 0.3^a	5.59 ± 1.21^a
−E2	99.7 ± 3.9^b	18.4 ± 0.3^a	19.3 ± 0.4^a,b	1.13 ± 0.10^b
FS−E2	104.2 ± 4.4^b	17.6 ± 0.5^a	19.9 ± 0.2^b	1.18 ± 0.10^b
TAM−E2	94.5 ± 2.9^b	17.3 ± 0.4^a	18.7 ± 0.4^a,b	1.57 ± 0.12^c
FS+TAM−E2	109.0 ± 4.8^b	17.7 ± 0.3^a	19.2 ± 0.4^a,b	1.46 ± 0.15^b,c
Experiment 2 (with E2 pellet implant)		Week 6	Week 12	Week 12
+E2	97.9 ± 1.0^a	18.3 ± 0.3^a	19.2 ± 0.6^a	2.80 ± 0.65^a
−E2	107.3 ± 3.4^a	17.9 ± 0.3^a	20.5 ± 0.5^a	0.95 ± 0.10^b
FS+E2	95.4 ± 3.5^a	18.5 ± 0.2^a	19.2 ± 0.4^a	2.95 ± 0.17^a
TAM+E2	96.6 ± 9.8^a	18.3 ± 0.3^a	19.0 ± 0.6^a	3.25 ± 0.48^a
FS+TAM+E2	92.0 ± 1.8^a	18.4 ± 0.4^a	18.4 ± 0.5^a	3.26 ± 0.72^a

Data are means ± SEM. Means with different superscripts within the same column and experiment are significantly different at P < 0.05 (one-way ANOVA followed by Tukey test).

†

Mice were sacrificed at week 13, whereas all other groups were sacrificed at week 14.

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