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Table 1

Effect of 10% FS and TAM on the body weight, food intake, and relative uterine weight *

Total food intake (6 weeks; g/mouse)Body weight (g)Uterine weight (mg/g body weight)
Experiment 1 (no E2 pellet implant)  Week 7 Week 13 Week 14 
 +E2  74.1 ± 2.4a 18.0 ± 0.3a 17.7 ± 0.3a 5.59 ± 1.21a 
 −E2 99.7 ± 3.9b 18.4 ± 0.3a 19.3 ± 0.4a,b 1.13 ± 0.10b 
 FS−E2 104.2 ± 4.4b 17.6 ± 0.5a 19.9 ± 0.2b 1.18 ± 0.10b 
 TAM−E2 94.5 ± 2.9b 17.3 ± 0.4a 18.7 ± 0.4a,b 1.57 ± 0.12c 
 FS+TAM−E2 109.0 ± 4.8b 17.7 ± 0.3a 19.2 ± 0.4a,b 1.46 ± 0.15b,c 
Experiment 2 (with E2 pellet implant)  Week 6 Week 12 Week 12 
 +E2 97.9 ± 1.0a 18.3 ± 0.3a 19.2 ± 0.6a 2.80 ± 0.65a 
 −E2 107.3 ± 3.4a 17.9 ± 0.3a 20.5 ± 0.5a 0.95 ± 0.10b 
 FS+E2 95.4 ± 3.5a 18.5 ± 0.2a 19.2 ± 0.4a 2.95 ± 0.17a 
 TAM+E2 96.6 ± 9.8a 18.3 ± 0.3a 19.0 ± 0.6a 3.25 ± 0.48a 
 FS+TAM+E2 92.0 ± 1.8a 18.4 ± 0.4a 18.4 ± 0.5a 3.26 ± 0.72a 
Total food intake (6 weeks; g/mouse)Body weight (g)Uterine weight (mg/g body weight)
Experiment 1 (no E2 pellet implant)  Week 7 Week 13 Week 14 
 +E2  74.1 ± 2.4a 18.0 ± 0.3a 17.7 ± 0.3a 5.59 ± 1.21a 
 −E2 99.7 ± 3.9b 18.4 ± 0.3a 19.3 ± 0.4a,b 1.13 ± 0.10b 
 FS−E2 104.2 ± 4.4b 17.6 ± 0.5a 19.9 ± 0.2b 1.18 ± 0.10b 
 TAM−E2 94.5 ± 2.9b 17.3 ± 0.4a 18.7 ± 0.4a,b 1.57 ± 0.12c 
 FS+TAM−E2 109.0 ± 4.8b 17.7 ± 0.3a 19.2 ± 0.4a,b 1.46 ± 0.15b,c 
Experiment 2 (with E2 pellet implant)  Week 6 Week 12 Week 12 
 +E2 97.9 ± 1.0a 18.3 ± 0.3a 19.2 ± 0.6a 2.80 ± 0.65a 
 −E2 107.3 ± 3.4a 17.9 ± 0.3a 20.5 ± 0.5a 0.95 ± 0.10b 
 FS+E2 95.4 ± 3.5a 18.5 ± 0.2a 19.2 ± 0.4a 2.95 ± 0.17a 
 TAM+E2 96.6 ± 9.8a 18.3 ± 0.3a 19.0 ± 0.6a 3.25 ± 0.48a 
 FS+TAM+E2 92.0 ± 1.8a 18.4 ± 0.4a 18.4 ± 0.5a 3.26 ± 0.72a 
*

Data are means ± SEM. Means with different superscripts within the same column and experiment are significantly different at P < 0.05 (one-way ANOVA followed by Tukey test).

Mice were sacrificed at week 13, whereas all other groups were sacrificed at week 14.

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