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Table 6

Pharmacokinetic parameters of Genexol-PMa

Dose mg/m2135 (n = 3)175 (n = 3)230 (n = 2)300 (n = 3)390 (n = 2)
Cmaxab (ng/ml) 1,357 ± 245 1,470 ± 208 4,682 ± 1,543 3,107 ± 1,476 6,567 ± 1,120 
AUC(0 → ∞) (ng*h/ml) 5,473 ± 1,296 5,740 ± 1,391 19,476 ± 4,004 11,580 ± 4,277 27,490 ± 8,297 
t1/2 β (h) 12.7 ± 4.2 12.5 ± 2.3 11.0 ± 1.9 11.4 ± 2.4 17.9 ± 1.0 
CLT (L/h/m2) 25.5 ± 5.3 32.0 ± 8.8 12.1 ± 2.5 29.3 ± 13.8 14.9 ± 4.5 
Dose mg/m2135 (n = 3)175 (n = 3)230 (n = 2)300 (n = 3)390 (n = 2)
Cmaxab (ng/ml) 1,357 ± 245 1,470 ± 208 4,682 ± 1,543 3,107 ± 1,476 6,567 ± 1,120 
AUC(0 → ∞) (ng*h/ml) 5,473 ± 1,296 5,740 ± 1,391 19,476 ± 4,004 11,580 ± 4,277 27,490 ± 8,297 
t1/2 β (h) 12.7 ± 4.2 12.5 ± 2.3 11.0 ± 1.9 11.4 ± 2.4 17.9 ± 1.0 
CLT (L/h/m2) 25.5 ± 5.3 32.0 ± 8.8 12.1 ± 2.5 29.3 ± 13.8 14.9 ± 4.5 
a

Data represent the mean ± SE.

b

Cmax, peak plasma concentration; AUC, area under the plasma concentration-time curve; t1/2β, elimination half-life; CLT, total body clearance.

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