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Table 4

Neuromuscular toxicities^a

Dose level	No. of patients/cycles	Neuropathy-motor							Neuropathy-sensory							Myalgia
Dose level	No. of patients/cycles			G1	G2	G3	G4	G1	G2	G3	G4	G1	G2	G3	G4
1	3/24	0	0	0	0	0	0	0	0	0	1	0	0
2	3/15	0	0	0	0	3	2	0	0	4	0	0	0
3	6/16	0	1	0	0	3	5	0	0	6	3	1	0
4	6/16	0	0	0	0	6	4	0	0	6	9	1	0
5	3/10	0	0	1	0	1	6	2	0	10	0	0	0

Dose level	No. of patients/cycles	Neuropathy-motor							Neuropathy-sensory							Myalgia
Dose level	No. of patients/cycles			G1	G2	G3	G4	G1	G2	G3	G4	G1	G2	G3	G4
1	3/24	0	0	0	0	0	0	0	0	0	1	0	0
2	3/15	0	0	0	0	3	2	0	0	4	0	0	0
3	6/16	0	1	0	0	3	5	0	0	6	3	1	0
4	6/16	0	0	0	0	6	4	0	0	6	9	1	0
5	3/10	0	0	1	0	1	6	2	0	10	0	0	0

^a

Expressed as the number of cycles with indicated side effects during the treatments.