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Table 2

Change in mammographic features after treatment with tamoxifen or placebo

Percentage of women changing to a parenchymal pattern of lower radiologic densityMean reduction in the estimated percentage of the breast showing radiological densities
Tamoxifen % (na)Placebo % (n)P                  bTamoxifen Mean ± SD (n)Placebo Mean ± SD (n)P                  b
All women 44.4 (36) 15.2 (33) 0.010 −9.4 ± 12.0 (36) −3.6 ± 5.3 (33) 0.010c 
Age at baseline (yr)       
<50 66.7 (21) 18.8 (16) 0.007 −12.1 ± 11.0 (21) −3.6 ± 4.5 (16) 0.003c 
≥50 13.3 (15) 11.8 (17) −5.7 ± 12.6 (15) −3.5 ± 6.2 (17) 0.540d 
Duration of treatment (yr)       
1.0–3.4 38.5 (13) 6.7 (15) 0.069 −6.9 ± 11.1 (13) −3.3 ± 3.5 (15) 0.282c 
3.5–5.0 47.8 (23) 22.2 (18) 0.114 −10.9 ± 12.4 (23) −3.8 ± 6.6 (18) 0.024c 
Percentage of women changing to a parenchymal pattern of lower radiologic densityMean reduction in the estimated percentage of the breast showing radiological densities
Tamoxifen % (na)Placebo % (n)P                  bTamoxifen Mean ± SD (n)Placebo Mean ± SD (n)P                  b
All women 44.4 (36) 15.2 (33) 0.010 −9.4 ± 12.0 (36) −3.6 ± 5.3 (33) 0.010c 
Age at baseline (yr)       
<50 66.7 (21) 18.8 (16) 0.007 −12.1 ± 11.0 (21) −3.6 ± 4.5 (16) 0.003c 
≥50 13.3 (15) 11.8 (17) −5.7 ± 12.6 (15) −3.5 ± 6.2 (17) 0.540d 
Duration of treatment (yr)       
1.0–3.4 38.5 (13) 6.7 (15) 0.069 −6.9 ± 11.1 (13) −3.3 ± 3.5 (15) 0.282c 
3.5–5.0 47.8 (23) 22.2 (18) 0.114 −10.9 ± 12.4 (23) −3.8 ± 6.6 (18) 0.024c 
a

Total number of women in category.

b

Fisher’s exact test. All Ps are two-sided.

c

t test with unequal variances.

d

t test with equal variances.

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