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Table 2

Prevalence of AGT codon 143 and 160 polymorphic genotypes in lung cancer cases and matched controls

Codon 143 genotype prevalenceCodon 160 genotype prevalence
Ile/IleIle/ValGly/GlyGly/Arg
African Americans     
Cases 70 (86)a 11 (14) 80 (99)a 1 (1) 
Controls 76 (94) 5 (6) 77 (96) 3 (4) 
OR (95% CI)b 2.3 (0.73–8.3)  NDc  
     
Caucasians     
Cases 41 (77) 12 (23) 53 (100) 0 (0) 
Controls 47 (85) 8 (15) 52 (98) 1 (2) 
OR (95% CI)b 2.0 (0.78–5.7)  ND  
     
Combined     
Cases 111 (83) 23 (17) 133 (99) 1 (1) 
Controls 123 (90) 13 (10) 129 (97) 4 (3) 
OR (95% CI)b 2.1 (1.01–4.7)  0.25 (0.013–1.7)  
Crude ORd 2.1 (χ2 = 3.98; P = 0.047)  0.24 (χ2 = 1.83; P = 0.182)  
Codon 143 genotype prevalenceCodon 160 genotype prevalence
Ile/IleIle/ValGly/GlyGly/Arg
African Americans     
Cases 70 (86)a 11 (14) 80 (99)a 1 (1) 
Controls 76 (94) 5 (6) 77 (96) 3 (4) 
OR (95% CI)b 2.3 (0.73–8.3)  NDc  
     
Caucasians     
Cases 41 (77) 12 (23) 53 (100) 0 (0) 
Controls 47 (85) 8 (15) 52 (98) 1 (2) 
OR (95% CI)b 2.0 (0.78–5.7)  ND  
     
Combined     
Cases 111 (83) 23 (17) 133 (99) 1 (1) 
Controls 123 (90) 13 (10) 129 (97) 4 (3) 
OR (95% CI)b 2.1 (1.01–4.7)  0.25 (0.013–1.7)  
Crude ORd 2.1 (χ2 = 3.98; P = 0.047)  0.24 (χ2 = 1.83; P = 0.182)  
a

Numbers in parentheses denote percentages.

b

OR and 95% CI were calculated by conditional logistic regression analysis as described in “Materials and Methods.” Race was not used as a variable for our regression model when examining African Americans and Caucasians separately.

c

ND, not determined.

d

OR, χ2, and P values were calculated using the Pearson’s χ2 test.

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