Meta-analysis for NQO1 Pro187Ser polymorphisms and lung cancer and bladder cancer risk stratified by smoking status and lung cancer histology
| . | No. studies . | OR for variant genotype* (95% CI) . | Test for heterogeneity P . | Egger's test P . | ||||
|---|---|---|---|---|---|---|---|---|
| Lung cancer | ||||||||
| White | ||||||||
| Ever smokers† | 6‡ | 1.08 (0.96-1.22) | 0.88 | 0.51 | ||||
| Never smokers† | 5§ | 0.97 (0.62-1.54)‡‡‡ | 0.08 | 0.90 | ||||
| Adenocarcinoma | 6∥ | 0.94 (0.79-1.12) | 0.96 | 0.16 | ||||
| Squamous cell carcinoma | 6∥ | 1.11 (0.92-1.33) | 0.43 | 0.04¶ | ||||
| Small cell | 4** | 1.01 (0.74-1.38) | 0.29 | 0.03¶ | ||||
| Asian | ||||||||
| Ever smokers†† | 4‡‡ | 0.78 (0.59-1.02) | 0.74 | 0.45 | ||||
| Never smokers†† | 4‡‡ | 0.82 (0.60-1.12) | 0.79 | 0.92 | ||||
| Adenocarcinoma | 4∥∥ | 0.88 (0.68-1.15) | 0.17 | 0.37 | ||||
| Squamous cell carcinoma | 3¶¶ | 1.28 (0.88-1.88) | 0.25 | 0.70 | ||||
| Bladder cancer | ||||||||
| White | ||||||||
| Ever smokers*** | 4††† | 1.14 (0.88-1.47) | 0.13 | 0.51 | ||||
| Never smokers*** | 4††† | 1.80 (1.18-2.76) | 0.22 | 0.05¶ | ||||
| . | No. studies . | OR for variant genotype* (95% CI) . | Test for heterogeneity P . | Egger's test P . | ||||
|---|---|---|---|---|---|---|---|---|
| Lung cancer | ||||||||
| White | ||||||||
| Ever smokers† | 6‡ | 1.08 (0.96-1.22) | 0.88 | 0.51 | ||||
| Never smokers† | 5§ | 0.97 (0.62-1.54)‡‡‡ | 0.08 | 0.90 | ||||
| Adenocarcinoma | 6∥ | 0.94 (0.79-1.12) | 0.96 | 0.16 | ||||
| Squamous cell carcinoma | 6∥ | 1.11 (0.92-1.33) | 0.43 | 0.04¶ | ||||
| Small cell | 4** | 1.01 (0.74-1.38) | 0.29 | 0.03¶ | ||||
| Asian | ||||||||
| Ever smokers†† | 4‡‡ | 0.78 (0.59-1.02) | 0.74 | 0.45 | ||||
| Never smokers†† | 4‡‡ | 0.82 (0.60-1.12) | 0.79 | 0.92 | ||||
| Adenocarcinoma | 4∥∥ | 0.88 (0.68-1.15) | 0.17 | 0.37 | ||||
| Squamous cell carcinoma | 3¶¶ | 1.28 (0.88-1.88) | 0.25 | 0.70 | ||||
| Bladder cancer | ||||||||
| White | ||||||||
| Ever smokers*** | 4††† | 1.14 (0.88-1.47) | 0.13 | 0.51 | ||||
| Never smokers*** | 4††† | 1.80 (1.18-2.76) | 0.22 | 0.05¶ | ||||
ORs are (C/T + T/T) vs C/C.
Ever smoking was defined differently in the studies: having smoked ≥100 cigarettes in lifetime (28, 38), having smoked for ≥6 months (40), having smoked at least 5 cigarettes per day (45), having smoked ≥5 cigarettes per day for at least 5 years (27), and not specifically defined (16, 26).
Included: refs. 16, 26, 27, 38, 40, 45.
Included: refs. 16, 26, 28, 38, 40.
Included: 16, 26, 28, 32, 40, 45.
Half or more then half of the study estimates were not directly presented in the original papers; therefore, the small Egger's test P here does not necessarily suggest publication bias.
Included (26, 28, 40, 45). (32) was excluded based on the sensitivity analysis for heterogeneity.
Ever smoking was defined differently in the studies: having smoked ≥100 cigarettes in lifetime (30), having smoked at least 1 cigarette per day for 1 year (41), and not specifically defined (36, 43).
Included: refs. 30, 36, 41, 43.
Included: refs. 33, 36, 41, 43.
Included: refs. 33, 36, 43.
Ever smoking was defined differently in the studies: having smoked ≥100 cigarettes in lifetime (46, 50); and not specifically defined (48, 53).
Included: refs. 46, 48, 50, 53.
Estimates derived from random effects models.